Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice  

作　　者：Dianzhi Hou Jian Tang Meili Huan Fang Liu Sumei Zhou Qun Shen 

机构地区：[1]Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Engineering and Technology Research Center of Food Additives,School of Food and Health,Beijing Technology and Business University,Beijing 100048,China [2]College of Food Science and Nutritional Engineering,Key Laboratory of Plant Protein and Grain processing,China,Agricultural University,Beijing 100083,China [3]COFCO Nutrition and Health Research Institute,Beijing 102209,China [4]College of Tobacco Science,Henan Agricultural University,Zhengzhou 450002,China

出　　处：《Food Science and Human Wellness》2022年第5期1259-1272,共14页食品科学与人类健康（英文）

基　　金：financially supported by National Key Research and Development Program of China(2021YFD1600604);China Agriculture Research System of MOF and MARA-Food Legumes(CARS-08-G19);Research Foundation for Youth Scholars of Beijing Technology and Business University(QNJJ2022-18)。

摘　　要：Dysbiosis of gut microbiota and its derived metabolites has been linked to the occurrence and development of nonalcoholic fatty liver disease.Our previous study has demonstrated that mung bean coat(MBC)might be mainly responsible for the beneficial effects of whole mung bean on high fat diet(HFD)-induced metabolic disorders.To investigate whether MBC,which is rich in dietary fiber and phytochemicals,can protect against HFD-induced hepatic steatosis in mice via targeting gut microbiota and its metabolites,we conducted this study.Results showed that MBC could effectively alleviative the obese phenotype,reduce the lipid accumulation and insulin resistance,and improve the hepatic oxidative stress and inflammatory response.Furthermore,MBC significantly prevented the HFD-induced changes in the structure and composition of gut microbiota,characterized by promoting the bloom of Akkermansia,Lachnospiraceae_NK4 A136_group,and norank_f_Muribaculaceae,and along with the elevated short-chain fatty acids concentrations.Non-targeted metabolomic analysis indicated a metabolism disorder that was obviously improved by MBC via regulating sphingolipid metabolism andα-linolenic acid metabolism.These findings suggested that MBC could improve hepatic steatosis through manipulating the crosstalk between gut microbiota and its metabolites.

关 键 词：MBC Hepatic steatosis Gut microbiota Short-chain fatty acids Metabolites 

分 类 号：TS210.9[轻工技术与工程—粮食、油脂及植物蛋白工程] TS201.4[轻工技术与工程—食品科学与工程]