Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress  

作　　者：GökselŞener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag Ozlem Sacan Asli Aykac 

机构地区：[1]Department of Pharmacology,Faculty of Pharmacy,Fenerbahce University,Istanbul 34758,Turkey [2]Department of Pharmacology,Institude of Health Sciences,Marmara University,Istanbul 34854,Turkey [3]Department of Medical Pathology Techniques,Vocational School of Health Services,Marmara University,Istanbul 34865,Turkey [4]Department of Biochemistry,Faculty of Engineering,Istanbul Universityş-Cerrahpasa,Istanbul 34320,Turkey [5]Department of Biophysics,Faculty of Medicine,Near East University,Nicosia 99138,Cyprus

出　　处：《Food Science and Human Wellness》2022年第5期1290-1298,共9页食品科学与人类健康（英文）

摘　　要：This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat model.The rats were divided into;control,scopolamine(1 mg/kg,i.p.),galantamine(1.5 mg/kg,i.p.)and PC extract(2 g/kg,p.o.)-treated scopolamine groups.On day 14,the novel object recognition test(NORT)and Morris water maze test(MWMT)were performed and then the rats were sacrificed.Scopolamine-induced cognitive impairments observed in the NORT and MWMT,significantly improved with PC extract and galantamine treatments.Scopolamine reduced M_(1) receptor expression,Bcl-2/Bax ratio,and glutathione levels in the hippocampus and frontal cortex,while malondialdehyde levels,caspase-3/9 expressions,and acetylcholinesterase(AChE)activity were found to be increased.On the other hand,PC and galantamine treatments reversed these changes.In conclusion,PC extract has shown an ameliorative effect on the spatial and recognition memory,M_(1) receptor expression,apoptosis,oxidative stress,and increased AChE activity.Thus,it was concluded that PC could prevent AD-like conditions and can be used as a functional food.However,since animal models do not completely mimic those of humans,based on the data obtained in this study,the importance of PC on human AD should be demonstrated in future studies.

关 键 词：Petroselinum crispum APOPTOSIS Spatial memory Recognition memory Oxidative stress M1 receptor 

分 类 号：TQ460.1[化学工程—制药化工]