Sox基因家族在水生动物性腺发育中的功能研究进展  

Research advance on the function of Sox gene family in aquatic animal gonadal development

作　　者：徐东杰 谢熙[1] 王蒙恩 王振亚 朱冬发[1] XU Dongjie;XIE Xi;WANG Mengen;WANG Zhenya;ZHU Dongfa(School of Marine Science,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学海洋学院,宁波315211

出　　处：《生物学杂志》2022年第3期97-102,共6页Journal of Biology

基　　金：国家自然科学基金项目(41776165,31802265)。

摘　　要：简述SRY related HMG-box(Sox)基因家族的发现、鉴定及分类依据,分析不同亚族成员氨基酸序列的相似性,发现同一亚族内不同基因HMG-box区高度保守其相似性在80%以上,不同亚族基因之间HMG-box区保守性较低。介绍Sox基因家族在水生动物性腺发育中的功能研究进展,探讨发现鱼类的性腺发育主要受到Sox9、Sox3和Sox8等B、E亚族成员的调控;在虾蟹类中,B、E亚族Sox基因也被报道参与性腺发育等生理过程的调控;在软体动物中,Sox9、Sox2和SoxH等基因在其性腺发育中可能扮演了重要的调控作用。迄今,Sox基因家族在水生动物性腺发育中的研究以基因克隆和表达谱系分析为主,其作用机理和分子通路还需要更加系统深入的研究,以期完善水生动物性腺发育的分子调控机制。The discovery,identification and classification of the SRY related HMG-box(Sox)gene family were reviewed.Analysis of amino acid sequences among different subfamilies revealed that HMG-box of the same subfamily genes is highly conserved more than 80%similarity,while HMG-box of different subfamily genes is lower.The study of Sox gene family in aquatic animal gonadal development was summarized and the gonadal development in fish mainly regulated by members of subfamilies B and E including Sox9, Sox3and Sox8was found.Sox genes belonging to subfamily B and E were also reported to be involved in the regulation of physiological processes such as gonadal development in shrimp and crab.In addition, Sox9, Sox2and SoxH genes might play vital roles irregulating gonadal development in mollusks.Studies on the Sox gene family in aquatic gonadal development have focused on gene cloning and expression profiling to date,but their mechanisms of action and molecular pathways needed to be studied more systematically and thoroughly in order to improve the molecular regulatory mechanisms of gonadal development in aquatic animals.

关 键 词：SOX基因家族 性腺发育 鱼类 甲壳动物 生理功能 

分 类 号：Q958.8[生物学—动物学]