老年2型糖尿病肾病患者肥胖与尿蛋白排泄的关系  

Relationship between Obesity and Urinary Protein Excretion in Elderly Patients with Type 2 Diabetic Nephropathy

作　　者：张辉 ZHANG Hui(Department of Internal Medicine,Ping'an Hospital of Xicheng District,Beijing,100035 China)

机构地区：[1]北京市西城区平安医院内科,北京100035

出　　处：《糖尿病新世界》2022年第9期14-17,21,共5页Diabetes New World Magazine

摘　　要：目的探究并分析老年2型糖尿病肾病患者肥胖与尿蛋白排泄的关系。方法选择2019年2月—2020年2月该院收治的老年2型糖尿病肾病患者100例,分组为正常组(n=42)、超重组(n=25)、肥胖组(n=33),观察并记录各组患者尿蛋白排泄情况。结果经重复方差分析,正常组、超重组、肥胖组患者的24 h尿微量白蛋白与尿微量白蛋白/肌酐差异有统计学意义(F=805.442、292.091,P<0.05)。随着患者肥胖程度的增加,患者mALB与ACR含量呈上升趋势,肥胖组患者尿蛋白含量明显高于正常组,差异有统计学意义(P<0.05)。不同腰围(WC)患者24 h尿mALB与ACR差异有统计学意义(F=910.988、299.590,P<0.05)。随着患者WC增加,患者尿蛋白(mALB与ACR)含量呈上升趋势,C组患者尿蛋白含量明显高于A组,差异有统计学意义(P<0.05)。不同腰臀比(WHR)患者24 h尿mALB与ACR差异有统计学意义(F=871.566、300.414,P<0.05)。随着患者腰臀比的增加,患者尿蛋白(mALB与ACR)含量呈上升趋势,F组患者尿蛋白含量明显高于D组,差异有统计学意义(P<0.05)。不同体脂患者24 h尿蛋白(mALB与ACR)差异有统计学意义(F=828.103、286.708,P<0.05)。随着患者体脂的增加,患者尿蛋白(mALB与ACR)含量呈上升趋势,I组患者尿蛋白含量明显高于G组,差异有统计学意义(P<0.05)。结论肥胖与老年2型糖尿病肾病患者尿蛋白排泄有一定的关系,即老年患者肥胖程度越高,尿蛋白水平越高。Objective To explore and analyze the relationship between obesity and urinary protein excretion in elderly patients with type 2 diabetic nephropathy.Methods A total of 100 elderly patients with type 2 diabetic nephropathy who were admitted to the hospital from February 2019 to February 2020 were selected.The groups were divided into normal group(n=42),overweight group(n=25),and obese group(n=33).The urinary protein excretion of patients in each group was observed and recorded.Results After repeated variance analysis,the 24-hour urinary microalbumin and urinary microalbumin/creatinine of the normal group,overweight and obesity group were significantly different,the difference was statistically significant(F=805.442,292.091,P<0.05).With the increase of the degree of obesity,the mALB and ACR contents of the patients showed an upward trend,and the urinary protein content of the obese group was significantly higher than that of the normal group,the difference was statistically significant(P<0.05).There were significant differences between 24 h urinary mALB and ACR in different WC patients,the difference was statistically significant(F=910.998,299.590,P<0.05).With the increase of waist circumference(WC),the urine protein(mALB and ACR)content of patients showed an upward trend.The urine protein content of patients in group C was significantly higher than that in group A,the difference was statistically significant(P<0.05).There were significant differences between 24 h urine mALB and ACR in patients with different waist-hip ratio(WHR),the difference was statistically significant(F=871.566,300.414,P<0.05).With the increase of waist-to-hip ratio,the urinary protein(mALB and ACR)content of patients showed an upward trend.The urinary protein content of patients in group F was significantly higher than that in group D,the difference was statistically significant(P<0.05).study meaning.The 24-hour urine mALB and ACR of patients with different body fat were significantly different,the difference was statistically significant(F=

关 键 词：蛋白尿 2型糖尿病 肾病 肥胖 

分 类 号：R587.2[医药卫生—内分泌]