基于DOHaD理念的膳食干预对妊娠期合并糖尿病患者体质指数的影响  

Effect of Dietary Intervention Based on DOHaD Concept on Body Mass Index in Pregnant Women with Diabetes Mellitus

作　　者：李晓霞 张丽兴[1] 胡雪芬 黎淑玲 冯燕 陈月玲 卢平[1] LI Xiaoxia;ZHANG Lixing;HU Xuefen;LI Shuling;FENG Yan;CHEN Yueling;LU Ping(Department of Obstetrics,Chang'an Hospital of Dongguan City,Dongguan,Guangdong Province,523800 China)

机构地区：[1]东莞市长安医院产科,广东东莞523800

出　　处：《糖尿病新世界》2022年第9期18-21,共4页Diabetes New World Magazine

摘　　要：目的探讨基于健康与疾病的发育起源(DOHaD)理念的膳食干预对妊娠期合并糖尿病(DM)患者体质指数(BMI)的影响。方法将该院2018年4月—2021年4月期间收治的80例妊娠期合并糖尿病患者按计算机随机分组法分为对照组和观察组,每组40例,两组患者均进行有氧运动干预,对照组辅以常规膳食干预,观察组辅以基于DOHaD理念的膳食干预。观察两组患者BMI、血糖指标、孕妇妊娠并发症及新生儿不良妊娠结局。结果干预后,观察组BMI(23.57±1.64)kg/m^(2)、空腹血糖(FPG)(5.13±1.34)mmol/L、餐后2 h血糖(2 hPG)(8.13±1.34)mmol/L及糖化血红蛋白(HbA1c)(6.60±1.20)%均低于对照组,差异有统计学意义(t=5.215、5.208、10.167、4.137,P<0.05);观察组孕妇妊娠并发症发生率12.5%及新生儿不良妊娠结局发生率7.5%均低于对照组,差异有统计学意义(P<0.05)。结论基于DOHaD理念的膳食干预通过控制妊娠期合并糖尿病患者的血糖水平,可有效改善患者体质指数,降低妊娠期并发症及新生儿不良妊娠结局的发生率。Objective To investigate the effect of dietary intervention based on the concept of developmental origin of health and disease(DOHaD)on body mass index(BMI)in patients with gestational diabetes mellitus(DM).Methods Eighty cases of gestational diabetes mellitus patients admitted to the hospital from April 2018 to April 2021 were randomly divided into control group and observation group,40 cases in each group.Both groups were given aerobic exercise intervention,the control group was supplemented with routine dietary intervention,and the observation group was supplemented with dietary intervention based on the DOHaD concept.The BMI,blood glucose indexes,pregnancy complications and neonatal adverse pregnancy outcomes of the two groups were observed.Results After intervention,the observation group had BMI(23.57±1.64)kg/m^(2),fasting blood glucose(FPG)(5.13±1.34)mmol/L,2 h postprandial blood glucose(2 hPG)(8.13±1.34)mmol/L and glycosylated hemoglobin(HbA1c)(6.60±1.20)%were lower than the control group,the difference was statistically significant(t=5.215,5.208,10.167,4.137,P<0.05).The incidence of pregnancy complications in the observation group was 12.5%and the incidence of neonatal adverse pregnancy outcomes was 7.5%in the observation group,the difference was statistically significant(P<0.05).Conclusion Dietary intervention based on DOHaD concept can effectively improve the body mass index of patients with diabetes mellitus during pregnancy by controlling the blood glucose level,and reduce the incidence of pregnancy complications and neonatal adverse pregnancy outcomes.

关 键 词：基于健康与疾病的发育起源理念 妊娠期合并糖尿病 体质指数 血糖 

分 类 号：R473.71[医药卫生—护理学]