柚皮苷药理作用及机制的研究进展  

Research progress on pharmacological effects and mechanism of naringin

作　　者：杨新荣 窦霞 李国峰 宋沁洁 李咸慰 吴红伟 李东辉 李越峰[1,2] YANG Xin-rong;DOU Xia;LI Guo-feng;SONG Qin-jie;LI Xian-wei;WU Hong-wei;LI Dong-hui;LI Yue-feng(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Province Chinese Medicine Pharmaceutical Process Engineering Research Center,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中药制药工艺工程研究中心,甘肃兰州730000 [3]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中草药》2022年第10期3226-3240,共15页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81460611);国家自然科学基金资助项目(81960713);国家自然科学基金资助项目(82160750);甘肃省教育厅产业支撑计划项目(2021CYZC-21);甘肃省中药制药工艺工程研究中心开放课题(ZYGY202003);科技创新服务平台建设项目(18JR2TA017);中央引导地方科技发展专项资金项目(30440323);甘肃省高等学校产业支撑计划项目(2020C-09);民生科技专项(科技特派员专题)(20CX9NA070)。

摘　　要：柚皮苷是骨碎补、枳实、枳壳、化橘红等中药的主要药效成分,具有抗骨质疏松、抗氧化、抗炎、抗菌、抗肿瘤、改善心肌损伤、改善肝损伤、防治糖尿病及并发症和调血脂等药理作用。通过分析归纳有关柚皮苷的大量文献,对其药理作用及其机制的研究进展进行综述,旨在为其合理应用和药物开发提供参考。Naringin is the main medicinal ingredient of traditional Chinese medicine such as Gusuibu(Drynariae Rhizoma),Zhishi(Aurantii Fructus Immaturus),Zhike(Aurantii Fructus),Huajuhong(Citri Grandis Exocarpium).It has various pharmacological effects such as anti-osteoporosis,anti-oxidation,anti-inflammatory,anti-bacterial,anti-tumor,improving myocardial damage,improving liver damage,preventing and treating diabetes complications and lowering blood lipids.By analyzing and summarizing a large number of literatures on naringin,research progress on pharmacological effects and mechanism of naringin were reviewed in this paper,so as to provide reference for its rational application and drug development.

关 键 词：柚皮苷 抗骨质疏松 抗氧化 抗炎 抗肿瘤 防治糖尿病并发症 

分 类 号：R282.710.5[医药卫生—中药学]