血清抗缪勒管激素联合性激素检测对多囊卵巢综合征的临床诊断价值  

Clinical diagnosis value of serum anti-Mullerian hormone combined with sex hormone detection for polycystic ovary syndrome

作　　者：钟磊[1] 肖作淼[1] 刘燕[2] 谢海燕[1] 邱玉梅[1] ZHONG Lei;XIAO Zuomiao;LIU Yan;XIE Haiyan;QIU Yumei(Department of Clinical Laboratory,People′s Hospital of Ganzhou City,Jiangxi Province,Ganzhou341000,China;Department of Reproduction,People′s Hospital of Ganzhou City,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市人民医院检验科,江西赣州341000 [2]江西省赣州市人民医院生殖医学科,江西赣州341000

出　　处：《中国当代医药》2022年第15期115-117,120,F0003,共5页China Modern Medicine

基　　金：江西省赣州市指导性科技计划任务(GZ2017ZSF162)。

摘　　要：目的探讨血清抗缪勒管激素(AMH)联合卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)检测对多囊卵巢综合征(PCOS)的临床诊断价值。方法回顾性分析2018年6月至2019年6月赣州市人民医院收治的50例PCOS患者的临床资料,将其纳入PCOS组,另外选取同期收治的30例其他不孕症患者为其他不孕症组,以及同期进行常规体检的30例健康者为健康对照组。所有入选者均检查AMH、FSH、LH、T水平,比较三组的AMH、性激素水平,并绘制受试者工作特征(ROC)曲线分析AMH、FSH、LH、T单项及联合检测诊断PCOS的临床价值。结果PCOS组的AMH、FSH、LH、T水平均高于其他不孕症组和健康对照组,其他不孕症组的AMH、FSH、LH、T水平均高于对照组,差异有统计学意义(P<0.05)。ROC曲线结果显示,AMH、FSH、LH、T单项及联合检测用于诊断PCOS的曲线下面积分别为0.720、0.693、0.534、0.703、0.989,具有一定的诊断效能,其中联合检测的诊断效能最高。结论在PCOS患者诊断中使用AMH联合FSH、LH、T具有较高的应用价值,可提高疾病检出率,为临床诊断提供更多参考。Objective To investigate the clinical diagnostic value of serum anti-Mullerian hormone(AMH)combined with follicle stimulating hormone(FSH),luteinizing hormone(LH)and testosterone(T)detection for polycystic ovary syndrome(PCOS).Methods Clinical data of 50 PCOS patients admitted to People′s Hospital of Ganzhou City from June 2018 to June 2019 were retrospectively analyzed and included in the PCOS group.In addition,30 other infertility patients admitted to People′s Hospital of Ganzhou City during the same period were selected as the other infertility group,and 30 healthy patients who underwent routine physical examination during the same period were selected as the healthy control group.The levels of AMH,FSH,LH and T in all the selected subjects were examined,and the levels of AMH and sex hormones in the three groups were compared.Receiver operating characteristic(ROC)curves were drawn to analyze the clinical value of single and combined detection of AMH,FSH,LH and T in the diagnosis of PCOS.Results The levels of AMH,FSH,LH and T in PCOS group were higher than those in other infertility groups and healthy control group,and the levels of AMH,FSH,LH and T in other infertility groups were higher than those in control group,the differences were statistically significant(P<0.05).ROC curve results showed that the areas under the curve of AMH,FSH,LH and T were 0.720,0.693,0.534,0.703 and 0.989 respectively for the diagnosis of PCOS,which had certain diagnostic efficiency,and the combined detection had the highest diagnostic efficiency.Conclusion The use of AMH combined with FSH,LH and T in the diagnosis of PCOS patients has high application value,which can increase the disease detection rate and provide more reference for clinical diagnosis.

关 键 词：多囊卵巢综合征 血清抗缪勒管激素 卵泡刺激素 黄体生成素 睾酮 诊断价值 

分 类 号：R711.75[医药卫生—妇产科学]