血小板生成研究进展  

Current Progress in Thrombopoiesis

作　　者：黄柏铭 刘翠翠 赵晶晶 王洪涛 周家喜 HUANG Baiming;LIU Cuicui;ZHAO Jingjing;WANG Hongtao;ZHOU Jiaxi(State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China)

机构地区：[1]中国医学科学院血液病医院(中国医学科学院血液学研究所),实验血液学国家重点实验室,国家血液系统疾病临床医学研究中心,细胞生态海河实验室,天津300020

出　　处：《中国细胞生物学学报》2022年第1期51-58,共8页Chinese Journal of Cell Biology

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费项目(批准号:2021-RC310-019);北京协和医学院中央高校基本科研业务费(批准号:3332020054);国家自然科学基金(批准号:81870099);京津冀基础研究合作专项[批准号:19JCZDJC65700(Z)]资助的课题。

摘　　要：血小板生成,即血小板颗粒由巨核细胞释放,进而在外周血逐步成熟的过程。随着解析血小板功能多样性以及高效再生策略的需求,对于血小板生成过程的全面认知显得尤为重要。然而,以往研究大多聚焦在造血干祖细胞和巨核细胞分化阶段,对于后期血小板生成过程的了解相对较少。该文对血小板生成过程中血小板形态、分子特征、功能的动态变化以及调控机制等进行了系统梳理,以期为理解血小板功能多样性、转录组异质性以及体外再生策略等方面提供新的思路。Thrombopoiesis,the maturation process of platelets released by mature megakaryocytes,is the last part of platelet generation in the peripheral blood.Currently,with the deepening understanding of platelet functional diversity and the need of efficient generation strategy,it is important to have a comprehensive cognition of thrombopoiesis.While past researches tend to focus on the differentiation of hematopoietic stem/progenitor cells and megakaryocytes,very little attention has been paid to the process of thrombopoiesis.In this paper,the changes of platelet morphology,RNA content and variety,as well as the molecular features and functions during thrombopoiesis were systematically reviewed.It will provide new insights into the platelet functional diversity,transcriptome heterogeneity and in vitro generation strategies.

关 键 词：血小板生成 前血小板 血小板前体 网织血小板 

分 类 号：R331.143[医药卫生—人体生理学]