稀土近红外二区纳米荧光影像探针及其生物医学应用  

Lanthanide-based NIR-II Fluorescent Nanoprobes and Their Biomedical Applications

作　　者：吴志芬 柯建熙[3] 刘永升 孙蓬明[2] 洪茂椿[3] Wu Zhifen;Ke Jianxi;Liu Yongsheng;Sun Pengming;Hong Maochun(Department of Gynecology,Quanzhou First Hospital Affiliated to Fujian Medical University,Fuzhou 350000;Laboratory of Gynecologic Oncology,Department of Gynecology,Fujian Maternity and Child Health Hospital,Affiliated Hospital of Fujian Medical University,Fuzhou 350001;State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002)

机构地区：[1]福建医科大学附属泉州第一医院妇科,福建泉州362000 [2]福建医科大学附属福建省妇幼保健院福建省妇儿重大疾病研究重点实验室,福建泉州362001 [3]中国科学院福建物质结构研究所结构化学国家重点实验室,福建泉州362002

出　　处：《化学学报》2022年第4期542-552,共11页Acta Chimica Sinica

基　　金：福建光电信息科学与技术创新实验室自主部署项目(No.2020ZZ114);中国科学院前沿科学重点研究计划(No.QYZDY-SSW-SLH025);国家自然科学基金(No.21871256);先进能源科学与技术广东省实验室基金(No.DJLTN0200/DJLTN0240)资助项目。

摘　　要：与传统的荧光生物成像相比,近红外二区(NIR-II)荧光生物成像技术具有空间分辨率高、信噪比高、成像深度大、自发荧光低、生物损伤小等优势,在活体成像、疾病诊断、无创治疗等领域应用前景广泛.在众多的NIR-II荧光纳米材料中,稀土近红外二区纳米荧光探针(NIR-IILn-NPs)因具有化学稳定性和光稳定性好、发射带窄、发光颜色和寿命可调等优点受到研究人员的广泛关注.因此,本文系统介绍了NIR-II Ln-NPs的设计策略、控制合成、发光调控、表面修饰、以及在生物医学应用方面的最新研究进展,并对该领域的技术难题及未来发展趋势进行了探讨.Compared with traditional fluorescent biological imaging,the second near-infrared(NIR-II)fluorescent biological imaging technology has the advantages of high spatial resolution,excellent signal-to-background ratio,large imaging depth,low autofluorescence,and less biological damage,which is widely used in disease diagnosis,non-invasive treatment and other fields.Among diverse NIR-II fluorescent nanomaterials,NIR-II emitting lanthanide based nanoprobes(NIR-II Ln-NPs)have received extensive attention owing to their exceptional merits like good photochemical-stability,narrow emission band,tunable emission colors and long-lived lifetime.In this review,we provide a comprehensive survey of the latest advances in developing lanthanide-based NIR-II emitting nanoprobes as deep-tissue-penetration fluorescent diagnostic and therapeutic agents,which cover from their design strategy,controllable synthesis,surface functionalization,optical properties as well as their biomedical applications,with an emphasis on heterogeneous and homogeneous in-vitro biodetection of tumor markers and multimodal bioimaging of various tumor tissues.Some future prospects and challenges in this rapidly growing field are finally summarized.

关 键 词：稀土纳米晶 近红外二区 荧光探针 生物医学应用 

分 类 号：O657.3[理学—分析化学] R318[理学—化学]