基于抑制扭转的分子内电荷转移(TICT)提升有机小分子荧光染料亮度及光稳定性  

Enhancing Brightness and Photostability of Organic Small Molecular Fluorescent Dyes Through Inhibiting Twisted Intramolecular Charge Transfer(TICT)

作　　者：许宁 乔庆龙[1] 刘晓刚 徐兆超 Xu Ning;Qiao Qinglong;Liu Xiaogang;Xu Zhaochao(Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,Liaoning Province,China;Zhang Dayu School of Chemistry,Dalian University of Technology,Dalian 116024,China;Singapore University of Technology and Design,Singapore 487372,Singapore)

机构地区：[1]中国科学院大连化学物理研究所,辽宁大连116023 [2]大连理工大学张大煜学院,辽宁大连116024 [3]新加坡科技设计大学,新加坡487372

出　　处：《化学学报》2022年第4期553-562,共10页Acta Chimica Sinica

基　　金：国家自然科学基金(22078314,21878286,21908216);大连化学物理研究所(DICPI202142,DICPI201938,DICPZZBS201805);新加坡教育部(MOE-MOET2EP10120-0007);新加坡科技设计大学(SUTD-ZJU(VP)201905)资助。

摘　　要：有机小分子荧光染料研究已有170余年历史,其结构和性能随着合成方法和应用需求的发展而不断革新,已被广泛应用于荧光标记、探针和生物成像中.近年来发展起来的超分辨荧光成像技术对有机小分子荧光染料的亮度、稳定性和开关性能等均提出了更高的要求,这为染料发展带来了新的机遇.当前,化学工作者也将更多精力聚焦在染料结构改造提升有机小分子荧光染料的亮度与光稳定性.激发态扭转的分子内电荷转移(TICT)是有机小分子荧光染料中主要的非辐射衰减途径之一.因而,抑制TICT能够很好地提升染料的亮度和光稳定性,并成为目前针对超分辨成像技术发展高亮度和光稳定性的有机小分子荧光染料的主要方法.本综述首先简要回顾了TICT的机制和发展过程,而后重点介绍近些年通过抑制TICT策略来提升不同结构有机小分子荧光染料光谱性能方面的进展.During the past 170 years,organic small molecular fluorescent dyes had been widely applied in fluorescence labeling,fluorescence probes and bioimaging.And their structures and performances continually evolved with development of synthetic method and application.However,the emerging super-resolution imaging put forward higher requirements at brightness,stability and switching performance of organic small molecular fluorescent dyes,which also offers new opportunity for developing novel dyes at the same time.So,chemists presently pay more attentions on brightness and photostability.Twisted intramolecular charge transfer(TICT),the major nonradiative decay channel in organic small molecular fluorescent dyes,seriously decrease brightness and photostability.Therefore,inhibiting TICT has became the crucial strategy to develop organic small molecular fluorescent dyes towards super-resolution imaging.This review will firstly demonstrate mechanism and development of TICT and emphatically introduce the progress in improving organic small molecular fluorescent dyes based on inhibiting TICT.

关 键 词：超分辨成像 有机小分子荧光染料 扭曲的分子内电荷转移 亮度 光稳定性 

分 类 号：TQ617.3[化学工程—精细化工] O657.3[理学—分析化学]