三七粉预防重症加强护理病房颅脑损伤昏迷患者并发静脉血栓栓塞症临床研究  

Clinical Study on Radix et Rhizoma Notoginseng Powder in Preventing Venous Thromboembolism in ICU Patients with Coma Caused by Traumatic Brain Injury

作　　者：张涛[1] 宋玉 杨惠芬[2] ZHANG Tao;SONG Yu;YANG Huifen

机构地区：[1]丽水市中心医院重症医学科,浙江丽水323000 [2]丽水市中心医院妇产科,浙江丽水323000

出　　处：《新中医》2022年第9期60-62,共3页New Chinese Medicine

摘　　要：目的:观察三七粉预防重症加强护理病房(ICU)颅脑损伤(TBI)昏迷患者并发静脉血栓栓塞症(VTE)的临床疗效。方法:选取86例TBI昏迷患者,采用随机数字表法分为观察组和对照组各43例。2组均接受标准治疗,对照组给予低分子肝素钙注射液皮下注射,观察组在对照组基础上给予生三七粉治疗。比较2组治疗前后凝血功能指标[D-二聚体(DD)、凝血酶原时间(PT)以及活化部分凝血活酶时间(APTT)]、VTE发生率及不良反应发生率。结果:治疗前,2组DD、PT、APTT水平比较,差异无统计学意义(P>0.05)。治疗后,2组DD、PT、APTT水平较治疗前升高,但观察组DD水平低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05);而观察组VTE发生率低于对照组,差异有统计学意义(P<0.05)。结论:三七粉在TBI昏迷患者中有着较高应用价值,对于改善患者血液高凝状态有一定效果,可以有效预防VTE。Objective:To observe the clinical effect of Radix et Rhizoma Notoginseng powder in preventing venous thromboembolism(VTE) in intensive care unit(ICU) patients with coma caused by traumatic brain injury(TBI).Methods:A total of 86 cases of TBI patients in coma were selected and divided into the observation group and the control group,with 43 cases in each group.Both groups were given standardized treatment;the control group was additionally given low-molecularweight heparin calcium injection subcutaneously,and the observation group was additionally treated with Radix et Rhizoma Notoginseng powder.The indexes of coagulation function [D-Dimer(DD),prothrombin time(PT) and activated partial thromboplastin time(APTT)] before and after treatment,as well as the incidences of VTE and adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of levels of DD,PT,and APTT between the two groups(P>0.05).After treatment,levels of DD,PT,and APTT in the two groups were increased when compared with those before treatment(P<0.05),but DD level in the observation groups was lower than that in the control group(P<0.05).There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.05);VTE incidence in the observation group was lower than that in the control group,the difference being significant(P<0.05).Conclusion:Radix et Rhizoma Notoginseng powder has high application value in TBI patients in coma,with a certain effect on the improvement of blood hypercoagulability,and an effective preventing effect on VTE.

关 键 词：颅脑损伤昏迷 重症加强护理病房 静脉血栓栓塞症 三七粉 低分子肝素钙注射液 预防 凝血功能 

分 类 号：R651.T5[医药卫生—外科学]