复元醒脑汤辅助治疗急性脑梗死临床研究  

Clinical Study on Fuyuan Xingnao Tang Assisting the Treatment of Acute Cerebral Infarction

作　　者：王爱丽[1] 王雪 朱太卿[1] WANG Aili;WANG Xue;ZHU Taiqing

机构地区：[1]郑州人民医院神经内科,河南郑州450002

出　　处：《新中医》2022年第9期67-71,共5页New Chinese Medicine

摘　　要：目的:观察复元醒脑汤辅助治疗对急性脑梗死的临床疗效及对血液流变学指标、血清低氧诱导因子-1α (HIF-1α)、过氧化物酶体增殖物激活受体γ (PPARγ)、白细胞介素-10 (IL-10)及胰岛素样生长因子-1 (IGF-1)水平的影响。方法:选取114例急性脑梗死患者随机分为研究组和对照组。对照组给予维持水电解质和酸碱平衡等常规对症治疗,研究组在对照组基础上给予复元醒脑汤辅助治疗。比较2组临床疗效及治疗前后血液流变学指标、血清HIF-1α、PPARγ、IL-10及IGF-1水平。结果:治疗2周后,研究组总有效率为89.47%,明显高于对照组的73.68%(P<0.05)。与同组治疗前比较,2组治疗后IGF-1水平升高(P<0.05),HIF-1α、PPARγ、IL-10水平和血液流变学指标均降低(P<0.05);与对照组治疗后比较,研究组血清IGF-1水平升高(P<0.05),HIF-1α、PPARγ、IL-10水平以及全血黏度高切、全血黏度低切、血浆黏度水平均明显降低(P<0.05)。治疗后,2组美国国立卫生院卒中量表(NIHSS)评分较治疗前降低,且研究组NIHSS评分低于对照组(P<0.05)。结论:复元醒脑汤辅助治疗急性脑梗死可显著改善血液流变学指标和神经功能,调节HIF-1α、PPARγ、IL-10、IGF-1的表达水平,提高疗效。Objective:To observe the clinical effect of Fuyuan Xingnao tang assisting the treatment of acute cerebral infarction and its effect on the levels of hemorheology indexes,hypoxia-inducible factor-1α(HIF-1α),peroxisome proliferator-activated receptor γ(PPARγ),interleukin-10(IL-10) and insulin-like growth factor-1(IGF-1).Methods:A total of114 cases of patients with acute cerebral infarction were randomly divided into the study group and the control group.The control group was given routine symptomatic treatment including maintaining water,electrolyte and acid-base balance,and the study group was additionally treated with Fuyuan Xingnao tang based on the treatment of the control group.The hemorheology indexes,and the levels of HIF-1α,PPARγ,IL-10 and IGF-1 in serum before and after treatment and the clinical effects in the two groups were compared.Results:After two-week treatment,the total effective rate was 89.47%in the study group,significantly higher than that of 73.68% in the control group(P<0.05).After treatment,the levels of IGF-1in the two groups were increased when compared with those before treatment(P<0.05),and the hemorheology indexes and the levels of HIF-1α,PPARγ and IL-10 were decreased(P<0.05);the IGF-1 level in serum in the study group was increased when compared with that in the control group(P<0.05),and levels of HIF-1α,PPARγ,IL-10,high shear viscosity of whole blood,low shear viscosity of whole blood and plasma viscosity were significantly decreased(P<0.05).After treatment,the scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were decreased when compared with those before treatment(P<0.05),and the NIHSS score in the study group was lower than that in the control group(P<0.05).Conclusion:Fuyuan Xingnao tang assisting the treatment of acute cerebral infarction can significantly improve hemorheology indexes and neurological function,regulate the expression levels of HIF-1α,PPARγ,IL-10 and IGF-1,and improve the curative effect.

关 键 词：急性脑梗死 复元醒脑汤 低氧诱导因子-1Α 过氧化物酶体增殖物激活受体Γ 神经功能 

分 类 号：R742[医药卫生—神经病学与精神病学]