补阳还五汤联合盐酸法舒地尔注射液对2型糖尿病合并足背动脉硬化气虚络阻型患者足背动脉血流动力学、氧化应激的影响  

Efficacy of Buyang Huanwu Decoction with fasudil hydrochloride for type 2 diabetes mellitus with dorsalis pedis arteriosclerosis of qi deficiency obstructing collaterals syndrome

作　　者：杨艳[1] 辛玲[1] 王红娜 YANG Yan;XIN Ling;WANG Hongna(Department of Geriatrics,Jinan Municipal Hospital of Traditional Chinese Medicine,Jinan,Shandong 250000)

机构地区：[1]山东省济南市中医医院老年病科,山东济南250000

出　　处：《河北中医》2022年第2期263-267,共5页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察补阳还五汤联合盐酸法舒地尔注射液对2型糖尿病合并足背动脉硬化气虚络阻型患者足背血流动力学、氧化应激的影响。方法将162例2型糖尿病合并足背动脉硬化气虚络阻型患者按照随机数字表法分为2组。对照组81例予盐酸法舒地尔注射液治疗,治疗组81例在对照组治疗基础上予补阳还五汤治疗。2组均治疗2周。比较2组治疗前后血糖[空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA_(1c))]、症状评分、足背动脉斑块数量、足背动脉内膜中层厚度、足背动脉血流动力学[足背动脉内径、收缩期峰值流速(PSV)、阻力指数(RI)]、凝血功能[D-二聚体(D-D)、纤维蛋白原(FIB)]及氧化应激[超氧化物歧化酶(SOD)、髓过氧化物酶(MPO)及硫氧还蛋白(Trx)]指标的变化。结果2组治疗后FPG、2 hPG、HbA_(1c)水平均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后各症状评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后足背动脉斑块数量、足背动脉内膜中层厚度、RI、PSV均较本组治疗前降低(P<0.05),足背动脉内径均升高(P<0.05),且治疗组治疗后足背动脉斑块数量、足背动脉内膜中层厚度、RI、PSV均低于对照组(P<0.05),足背动脉内径高于对照组(P<0.05)。2组治疗后D-D、FIB水平均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后SOD、Trx水平均较本组治疗前升高(P<0.05),MPO水平均降低(P<0.05),且治疗组治疗后SOD、Trx水平均高于对照组(P<0.05),MPO水平低于对照组(P<0.05)。结论补阳还五汤联合盐酸法舒地尔注射液治疗可明显改善2型糖尿病合并足背动脉硬化气虚络阻型患者临床症状,促进足背血液循环,减轻氧化应激,有利于患者病情恢复。Objective To observe the impact of Buyang Huanwu Decoction with fasudil hydrochloride injection on hemodynamics and oxidative stress of type 2 diabetes mellitus(T2DM)patients with dorsalis pedis arteriosclerosis(qi deficiency obstructing collaterals syndrome).Methods Totally 162 T2DM patients with dorsalis pedis arteriosclerosis(qi deficiency obstructing collaterals syndrome)were randomly divided into two group:treatment group(n=81)and control group(n=81);apart from fasudil hydrochloride injection,and treatment group additionally received Buyang Huanwu Decoction.The treatment period was two weeks,the key observation was blood glucose including fasting plasma glucose(FPG),two hour plasma glucose(2 hPG),hemoglobin A_(1c)(HbA_(1c)),traditional Chinese medicine(TCM)symptom score,patch numbers and intima-media thickness(IMT),hemodynamics index of peak systolic velocity(PSV),resistance index(RI),coagulation function(D-dimer[D-D]),fibrinogen(FIB),oxidative stress indexes of superoxide dismutase(SOD),myeloperoxidase(MPO),thioredoxin protein(Trx).Results After treatment,FPG,2 hPG,HbA_(1c) levels in groups were decreased(P<0.05),which were lower in treatment group than in control group(P<0.05);TCM symptom scores in groups were decreased(P<0.05),which in treatment group was lower than in control group(P<0.05);patch numbers,IMT,RI and PSV in groups were decreased(P<0.05),treatment group was more prevalent(P<0.05);patch diameter in groups was increased(P<0.05),which was more common in treatment group(P<0.05);D-D and FIB in groups were decreased(P<0.05),which were decreased in treatment group than in control group(P<0.05);SOD and Trx in groups were increased(P<0.05),treatment group were higher than control group(P<0.05),while MPO in groups was decreased(P<0.05),improvement of which in treatment group was significantly better(P<0.05).Conclusion For with T2DM patients with dorsalis pedis arteriosclerosis(qi deficiency obstructing collaterals syndrome),the above combination therapy can significantly improve the clinical symptoms,

关 键 词：补阳还五汤 糖尿病 2型 动脉硬化 中西医结合疗法 

分 类 号：R587.290.58[医药卫生—内分泌]