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作 者:张铁军[1,2,3] 郭海彪[4] 许浚[1,2,3] 徐旭[1,2,3] 王德勤[4] 韩彦琪[1,2] 张洪兵[1,2] 李楚源[4] 刘昌孝[1,3] Zhang Tiejun;Guo Haibiao;Xu Jun;Xu Xu;Wang Deqin;Han Yanqi;Zhang Hongbing;Li Chuyuan;Liu Changxiao(Tianjin Institute of Pharmaceutical Research,Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Tianjin 300301,China;Tianjin Institute of Pharmaceutical Research,National&Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine,Tianjin 300301,China;Tianjin Institute of Pharmaceutical Research,State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin 300301,China;Guangzhou Baiyun Mountain and Hutchison Whampoa Ltd.,Guangzhou 510515,China)
机构地区:[1]天津药物研究院/天津市中药质量标志物重点实验室,天津300301 [2]天津药物研究院/中药现代制剂与质量控制技术国家地方联合工程实验室,天津300301 [3]天津药物研究院/释药技术与药代动力学国家重点实验室,天津300301 [4]广州白云山和记黄埔中药有限公司,广东广州510515
出 处:《世界科学技术-中医药现代化》2022年第1期1-8,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基 金:国家自然科学基金委员会重点项目(81830111):基于“成分构成-靶标网络-生物效应”多维整合的中药质量标志物发现与确认,负责人:许海玉;国家中医药管理局国际合作司中医药国际合作专项(0610-2140NF020630):中国-德国中药与植物药创新研发国际合作基地,负责人:刘昌孝。
摘 要:三七为常用中药材,具有散瘀、止血,消肿定痛的功效。三七粉作为三七市场应用的主要形式之一,市场逐年增大。现行标准难以评价和控制三七粉“多重功效”的质量特点。本课题组在系统辨识三七粉化学物质组及其传递规律的基础上,采用网络药理学和体内、体外模型,研究并阐明了三七粉的活血、心肌与血管保护、止血以及消肿定痛的药效物质基础;进一步结合成分的特有性分析,确定了三七粉的质量标志物;在此基础上,建立了基于质量标志物的三七粉的指纹图谱及“一测多评”的多指标含量测定方法,为建立三七粉整体质量控制方法提供了理论与实验证据。Panax Notoginseng is a commonly used Chinese herbal medicine, which has the effects of dispersing blood stasis, hemostasis, detumescence and analgesia. Panax Notoginseng Powder as one of the main forms of market application of Panax Notoginseng, the market is increasing year by year. The current standards are difficult to evaluate and control the quality characteristics of "multiple effects" of Panax Notoginseng Powder. Firstly, on the basis of systematic identification of chemical substance group of Panax Notoginseng Powder and its transfer law, our group studied and clarified its pharmacodynamic material basis in promoting blood circulation, myocardial and vascular protection, hemostasis, detumescence and pain relief by using network pharmacology and in vivo and in vitro models.Furthermore, the quality markers of Panax Notoginseng Powder were determined by the specificity analysis of components. Finally, the fingerprint and multi index content determination method were established for the quality marker of Panax Notoginseng Powder, which provided theoretical and experimental evidence for the establishment of its overall quality control method.
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