腰椎间盘突出症慢性疼痛的脑机制研究进展  

Research Progress on the Brain Mechanism of Chronic Pain in Lumbar Disc Herniation

作　　者：张天龙 赵继荣 陈祁青[1] 赵宁[1] 朱宝 马同 薛旭 杨涛 Zhang Tianlong;Zhao Jirong;Chen Qiqing;Zhao Ning;Zhu Bao;Ma Tong;Xue Xu;Yang Tao(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730030,China;School of Clinical Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院,兰州730030 [2]甘肃中医药大学中医临床学院,兰州730050

出　　处：《世界科学技术-中医药现代化》2022年第1期277-282,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会地区项目(81760877):基于RS-fMRI及ERK-CREB-BDNF信号通路杜仲腰痛丸干预腰椎间盘突出症慢性疼痛的脑机制研究,负责人:赵继荣;国家中医药管理局中医药标准化项目(GZY-FJS-2020-213):中医病证诊断疗效标准示范性修订—腰椎间盘突出证,负责人:赵继荣。

摘　　要：腰椎间盘突出症(lumbar disc herniation,LDH)导致的慢性腰腿痛已经成为影响广大人民群众生活的严重疾患之一,对社会生产和社会经济造成了严重负担,LDH慢性疼痛的诊疗虽然取得了长足发展,但是其病因病理复杂多变,目前仍是世界性的医疗难题之一。近年来,随着细胞生物、分子蛋白、医学物理等技术的快速发展,推动着LDH慢性疼痛的病理机制由病灶局部的研究转向大脑功能与结构区的探索,LDH慢性疼痛引起大脑功能与结构区的异常改变引起了众多学者的关注,这一发现为进一步探索LDH慢性疼痛机制提供了丰富的思路。本文对LDH慢性疼痛的脑机制展开现代医学和中医学的最新综述,深入探讨LDH慢性疼痛的脑机制,以期为临床治疗及研究该病提供科研思路与科学基础。Chronic low back and leg pain caused by lumbar disc herniation(LDH) has become one of the serious diseases affecting the lives of the general public, causing a serious burden on social production and social economy.Although the diagnosis and treatment of chronic pain in LDH has made great progress. Its etiology and pathology are complex and changeable, and it is still one of the world’s medical problems. In recent years, with the advancement of molecular, cellular, imaging and other technologies, the pathological mechanism of chronic pain in LDH has shifted from the study of local lesions to the exploration of brain function and structure. Chronic pain caused by LDH causes abnormal changes in brain function and structure. It has attracted the attention of many scholars, and this finding provides a wealth of ideas for further exploring the mechanism of chronic pain in LDH. In this paper, the latest review of modern medicine and traditional Chinese medicine was carried out on the brain mechanism of chronic pain in LDH, and the brain mechanism of chronic pain in LDH was discussed in depth, in order to provide scientific research ideas and scientific basis for clinical treatment and research of the disease.

关 键 词：腰椎间盘突出症 慢性疼痛 信号通路 脑机制 综述 

分 类 号：R319[医药卫生—基础医学]