补肾疏肝方对早发性卵巢功能不全合并不孕症患者妊娠成功率的影响  

Effect of Bushen Shugan Formula on Success Rate of Pregnancy in Patients with POI Accompanied with Infertility

作　　者：何春晖 李玲玲[2] 余炳莹 HE Chunhui;LI Lingling;YU Bingying(Xinyang Hospital of Traditional Chinese Medicine,Xinyang 464000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]信阳市中医院,河南信阳464000 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医药信息》2022年第6期72-75,共4页Information on Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项项目(2018ZY2068)。

摘　　要：目的:探讨补肾疏肝方治疗早发性卵巢功能不全(POI)合并不孕症患者的疗效及对妊娠成功率的影响。方法:将符合纳入标准的158例POI合并不孕症患者随机分为观察组和对照组,各79例。对照组予常规西药治疗,观察组在对照组基础上给予补肾疏肝方治疗,治疗周期均为3个月经周期,治疗结束后均随访6个月。比较两组患者治疗前后的中医证候积分、子宫内膜厚度,以及血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、抗苗勒氏管激素(AMH)水平和临床疗效;统计随访期间的妊娠成功率以及治疗期间的不良反应发生率。结果:治疗前两组各指标比较,无统计学意义(P> 0.05)。治疗后各观察指标均较治疗前改善(P <0.05)。治疗后观察组的治疗总有效(93.67%,74/79)率高于对照组(82.28%,65/79)(P <0.05);观察组中医证候积分低于对照组(P <0.05),子宫内膜厚度、AMH水平高于对照组(P <0.05);观察组FSH、LH水平均低于对照组(P <0.05),E2水平高于对照组(P <0.05);观察组不良反应发生率低于对照组,妊娠成功率高于对照组(P <0.05)。结论:相比于常规西药治疗,补肾疏肝方治疗POI合并不孕症患者疗效确切,可有效减轻患者临床症状,调节性激素水平,并提高妊娠成功率,安全性高。Objective:To explore the effect of Bushen Shugan Formula on success rate of pregnancy in patients with premature ovarian insufficiency(POI)accompanied with infertility.Methods:A total of 158 patients with POI accompanied with infertility were randomly divided into the observation group and the control group,with 79cases in each group.The control group was treated with routine western medication;on which basis,the observation group was also treated with Bushen Shugan Formula.The treatment duration was 3 menstrual cycles and then followed up for 6 months.The score of TCM syndrome,endometrial thickness,serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2)and anti-Müllerian hormone(AMH)were compared between before and after the treatment in the two groups.The clinical efficacy was also compared between the two groups.The success rate of pregnancy during follow-up and incidence of adverse reactions during treatment were statistically analyzed in the two groups.Results:There were no statistical differences in all indexes between the two groups before the treatment(P > 0.05);which were all improved after the treatment in the two groups(P < 0.05).The total effective rate was 93.67%(74/79)in the observation group,which was significantly higher than 82.28%(65/79)in the control group(P < 0.05).The score of TCM syndromes was lower in the observation group than that in the control group(P < 0.05).Endometrial thickness and AMH were higher in the observation group than those in the control group(P < 0.05).The levels of FSH and LH were lower in the observation group than those in the control group(P < 0.05),whereas the level of E2was higher in the observation group than that in the control group(P < 0.05).The incidence of adverse reactions was lower in the observation group than that in the control group(P < 0.05).The success rate of pregnancy was higher in the observation group than that in the control group(P < 0.05).Conclusion:Compared with routine western medication,the curative effect of B

关 键 词：早发性卵巢功能不全 不孕症 补肾疏肝方 性激素 妊娠成功率 

分 类 号：R271.14[医药卫生—中医妇科学]