铜催化噁唑硼烷一锅法氢转移:芳香醛的还原胺化反应研究  

Copper Catalyzed One Pot Transfer Hydrogenation of Oxazaborolidine Complex:Reductive Amination of Aromatic Aldehydes

作　　者：GIMAH AMY SAMBOLLAH 熊万金 李雷 伍建军 唐鋆磊[1] 周太刚 GIMAH AMY SAMBOLLAH;XIONG Wanjin;LI Lei;WU Jianjun;TANG Junlei;ZHOU Taigang(College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China;Research Institute of Tianfu New Energy, Chengdu 610299, China)

机构地区：[1]西南石油大学化学化工学院,四川成都610500 [2]天府新能源研究院,四川成都610299

出　　处：《合成化学》2022年第6期459-465,共7页Chinese Journal of Synthetic Chemistry

基　　金：四川省科技计划项目(2021YFH0161);西南石油大学自然科学“揭榜挂帅”项目(2021JBGS07);国家自然科学基金青年基金资助项目(21602184)。

摘　　要：通过三羟甲基氨基甲烷与BH_(3)·THF反应制得1,3,2-噁唑硼烷络合物,并以其作为氢源,以甲磺酸铜为催化剂,在温和反应条件下(60℃,24 h),实现了芳香醛的一锅法氢转移还原胺化,以45%~80%的产率得到20个二级胺类化合物,其结构经^(1)H NMR确证。We have developed a copper catalyzed one pot transfer hydrogenation of oxazaborolidine complex and reductive amination of aromatic aldehydes.The reaction was processed under mild condition(60℃,24 h).Copper(II)methane sulfonate was used as a metal catalyst,1,3,2-oxazolborane complex was prepared in situ from tris(hydroxymethyl)aminomethane with BH_(3)·THF as the hydrogen source.Twenty amine derivatives were synthesized in moderate to good yields(45%~80%),its structure was confirmed by ^(1)H NMR.

关 键 词：铜催化 一锅法 胺 1 3 2-噁唑硼烷 氢转移 合成 还原胺化 

分 类 号：O625.6[理学—有机化学]