基于数据挖掘的肖承悰治疗子宫内膜异位症及子宫腺肌病用药规律研究  

Experience of Xiao Chengzong in Treating Endometriosis and Adenomyosis Based on Data Mining

作　　者：杨绿 刘雁峰[2] 肖承悰[2] YANG Lü;LIU Yanfeng;XIAO Chengzong(Beijing University of Chinese Medicine,Beijing 100029,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东直门医院,北京100700

出　　处：《中国中医药信息杂志》2022年第6期13-19,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家重点研发计划(2018YFC1704100);国家中医药管理局全国名老中医药专家传承工作室建设项目(2011年)。

摘　　要：目的利用数据挖掘技术,分析肖承悰教授治疗子宫内膜异位症(EM)及子宫腺肌病(AM)的用药规律,归纳其治疗相关疾病的经验。方法收集2019年1月1日-2021年6月1日肖承悰教授门诊EM及AM患者病历资料,筛选后录入中医传承辅助平台V2.5,通过频次统计、关联规则分析、复杂系统熵聚类等对用药规律进行分析。结果共纳入患者49例,涉及处方103首。治疗EM高频药物为延胡索、茯苓、牡丹皮、巴戟天、胡芦巴等,治疗AM高频药物为巴戟天、延胡索、胡芦巴、片姜黄、牡丹皮等;治疗EM、AM的药物药性以温性为主,药味以苦、辛、甘为主;复杂系统熵聚类分析得出治疗EM新方2个、AM新方2个。结论肖承悰教授认为EM、AM的共同病机为肾阳不足、寒凝血瘀,治以温阳散寒、祛瘀通脉、行气止痛之法,用药强调温而不燥、扶正祛邪。Objective To analyze Professor Xiao Chengzong’s medication rules in the treatment of endometriosis(EM)and adenomyosis(AM)using data mining technology;To summarize Professor Xiao Chengzong’s experience in the treatment of such diseases.Methods The medical records of patients with EM or AM who visited Professor Xiao Chengzong’s clinic from January 1,2019 to June 1,2021 were collected.The data were screened and entered into the Traditional Chinese Medicine Inheritance Auxiliary Platform V2.5.Through frequency statistics,association rules,complex system entropy clustering,etc.,the medication rules were analyzed.Results This study included 49 patients and 103 prescriptions.The most frequently used drugs for EM were Corydalis Rhizoma,Poria,Moutan Cortex,Morinda Officinalis Radix,Trigonellae Semen,etc.;the most frequently used drugs for AM were Morinda Officinalis Radix,Corydalis Rhizoma,Trigonellae Semen,Wenyujin Rhizoma Concisum,Moutan Cortex,etc.;warm drugs were most frequently used for EM and AM;the main flavors were bitter,pungent and sweet;two new EM prescriptions and two new AM prescriptions were obtained by entropy clustering analysis of complex systems.Conclusion Professor Xiao Chengzong believes that the common pathogenesis of EM and AM is deficiency of kidney yang,cold coagulation and blood stasis.The treatment is based on warming yang and dispersing cold,removing blood stasis and activating qi to relieve pain.She emphasizes the principle of warming but not dryness,strengthening vital qi and eliminating pathogenic factors in medication.

关 键 词：子宫内膜异位症 子宫腺肌病 名老中医经验 肖承悰 数据挖掘 

分 类 号：R2-05[医药卫生—中医学] R271.91