纳米科技在骨关节炎影像中的临床应用前景和机遇  

Clinical prospects and opportunities for nanotechnology applied to imaging of osteoarthritis

作　　者：鹿蓉 陈爽[1] LU Rong;CHEN Shuang(Department of Radiology,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院放射诊断科,上海200040

出　　处：《外科研究与新技术》2022年第1期1-8,共8页Surgical Research and New Technique

基　　金：国家自然科学基金项目(81671652)。

摘　　要：骨关节炎(osteoarthritis,OA)是最常见的骨关节病变,目前认为OA不再单纯只是一种退行性病变,而是一种系统性、代谢性、炎症性疾病。OA是老年人残疾的主要原因和社会成本的来源之一。许多新技术和材料正在进行临床前开发,以解决这一多因素疾病。在诊断方面,用于MRI、CT和PA的纳米造影剂提供了更多关于软骨结构和病变定性和定量的信息,这是早期OA的已知生物标记物。纳米医学发展的机遇,以及成像和诊断的未来前景极其广阔。Osteoarthritis(OA)is the most common bone and joint disease.At present,it is considered no longer just a degenerative disease,but a systemic,metabolic,and inflammatory disease.OA is the main cause of disability of the elderly and one of the sources of social costs.Many new technologies and materials are under preclinical development to address this multifactorial disease.In terms of diagnosis,nano contrast agents for MRI,CT,and PA provide a lot of qualitative and quantitative information about cartilage structure and lesions,which are known biomarkers of OA.The opportunities for the development of nano medicine and the prospects of imaging and diagnosis based on nanotechnology are extremely broad.

关 键 词：软骨成像 高级成像 纳米科技 

分 类 号：R445.2[医药卫生—影像医学与核医学]