Phase transferring luminescent gold nanoclusters via single-stranded DNA  

作　　者：Yu Li Hui Lu Zhibei Qu Mingqiang Li Haoran Zheng Peilin Gu Jiye Shi Jiang Li Qian Li Lihua Wang Jing Chen Chunhai Fan Jianlei Shen 

机构地区：[1]Division of Physical Biology,CAS Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai,201800,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai,200240,China [4]Shanghai Synchrotron Radiation Facility,Zhangjiang Laboratory,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201210,China [5]Shanghai Key Laboratory of Green Chemistry and Chemical Processes,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai,200127,China

出　　处：《Science China Chemistry》2022年第6期1212-1220,共9页中国科学（化学英文版）

基　　金：supported by the National Key R&D Program of China (2020YFA0908104);the National Natural Science Foundation of China (91953106, 92056117, 21904087, 21705159);the Shanghai Municipal Science and Technology Commission (19JC1410300,19ZR1474600, 20dz1101000, 21QA1404800);the Fundamental Research Funds for the Central Universities and Shanghai Jiao Tong University。

摘　　要：Atomically precise gold nanoclusters(Au NCs) are an emerging class of quantum-sized nanomaterials with discrete electronic energy levels, which has led to a range of attractive electronic and optical applications. Nevertheless, the lack of general methods to transfer Au NCs protected with hydrophobic ligands to an aqueous solution hampers their use in physiological settings. Here,we developed a single-stranded DNA-based approach that could transfer ~90% hydrophobic Au NCs into an aqueous solution.We experimentally and theoretically established that multivalent electrostatic and hydrophobic interactions between DNA strands and the hydrophobic ligand layer on Au NCs resulted in monodispersed DNA-coated Au NCs with high physical integrity in an aqueous solution. The fluorescence quantum yield of Au NCs was increased by ~13 fold, and surface-constrained DNA retained the specific recognition ability for biosensing. We further demonstrated the versatility of this phase-transfer approach, which thus holds great potential to advance biological and medical applications of Au NCs.

关 键 词：gold nanoclusters DNA MONODISPERSED phase transfer biological application 

分 类 号：R318[医药卫生—生物医学工程] O657.3[医药卫生—基础医学] TB383.1[理学—分析化学]