细胞因子介导的骨骼肌系统与免疫系统间调控网络  

Cytokine-Mediated Regulatory Networks Between Skeletal Muscle System and Immune System

作　　者：张子涵 杨欢 黄庆生[1] 杨慧[1,2] ZHANG Zihan;YANG Huan;HUANG Qingsheng;YANG Hui(School of Life Sciences,Northwestern Polytechnical University,Xi’an 710072,China;Biomechanics&Medical Engineering Research Center of Special Environment,Northwestern Polytechnical University,Xi’an 711072,China)

机构地区：[1]西北工业大学生命学院,西安710072 [2]西北工业大学特殊环境生物力学医学工程研究中心,西安710072

出　　处：《医用生物力学》2022年第2期374-378,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(31800781,11722220);陕西省自然科学基金重点项目(2020JZ-11)。

摘　　要：骨骼肌系统与免疫系统之间存在着紧密的调控网络,两者共同参与骨骼肌系统和免疫系统的功能调节和应答,细胞因子则是构成这一调控网络的重要信号分子。骨骼肌萎缩所产生的细胞因子与骨骼肌加负荷力学刺激所产生的细胞因子具有不同的组成与生物学效应;正常免疫系统与异常免疫功能也可通过不同细胞因子的协同作用对骨骼肌施加影响,据此形成两大系统间复杂的调控网络。本文对细胞因子介导的骨骼肌系统与免疫系统间调控网络展开综述,以期为骨骼肌萎缩的防治和机体免疫功能提高的力学干预提供理论依据。There is a tight regulatory network between the skeletal muscle system and the immune system,and they are jointly involved in functional regulation and response of the skeletal muscle system and the immune system.Cytokines are important signaling molecules that constitute this regulatory network.The cytokines produced by skeletal muscle atrophy and the cytokines produced by mechanical stimulation of skeletal muscle have different compositions and biological effects.The normal immune system and abnormal immune function can also affect skeletal muscle through the synergistic effect of different cytokines.According to this,a complex regulatory network between the two major systems is formed.The cytokine-mediated regulatory network between the skeletal muscle system and the immune system was reviewed in order to provide the theoretical basis for prevention and treatment of the skeletal muscle atrophy and mechanical intervention of the body immune function.

关 键 词：骨骼肌 免疫 细胞因子 力学刺激 

分 类 号：R318.01[医药卫生—生物医学工程]