复发性流产者孕早期监测雌激素、孕酮、β-人绒毛膜促性腺激素预测流产再发生的临床价值  

Value of dynamic monitoring of the levels of estrogen,progesterone,and β-human chorionic gonadotropin of pregnant women with recurrent spontaneous abortion during the first trimester of pregnancy for predicting their spontaneous abortion again

作　　者：王雪梅[1] WANG Xuemei(People's Hospital of Ganzi Tibetan Autonomous Prefecture,Kangding,Sichuan Province,626000)

机构地区：[1]四川省甘孜藏族自治州人民医院,康定626000

出　　处：《中国计划生育学杂志》2022年第6期1318-1322,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨复发性流产患者孕早期雌二醇(E_(2))、孕酮(P)、β-人绒毛膜促性腺激素(β-HCG)水平变化及预测流产再发生价值。方法:回顾收集2017年8月—2020年10月于本院妇产科就诊的复发性流产再妊娠孕妇89例(病例组)及无自然流产史正常早孕孕妇50例(对照组)临床资料,病例组根据再妊娠情况分为流产组(32例)及未流产组(57例)。各组均于孕早期(孕4、6、8、10、12周)检测血清E_(2)、P、β-HCG水平,分析各组性激素差异并探讨各时点指标对复发性流产再妊娠孕妇妊娠结局的预测价值。结果:孕4、6、8、10、12周时孕早期各时间点E_(2)、P、β-HCG水平病例组均低于对照组,且流产组低于未流产组(均P<0.05)。孕4、6、8、10、12周时各时间点E_(2)预测流产发生的曲线下面积(AUC)为0.743、0.755、0.748、0.769、0.748,各时间点P的AUC为0.857、0.852、0.707、0.884、0.730,各时间点β-HCG的AUC为0.617、0.777、0.919、0.900、0.904。结论:复发性流产者孕早期E_(2)、P、β-HCG水平异常,且发生流产者更低,检测各性激素水平有助于早期预测流产再发生,为及时干预提供参考。Objective:To investigate the changes of the levels of estrogen(E_(2)),progesterone(P),andβ-human chorionic gonadotropin(β-HCG)of pregnant women with recurrent spontaneous abortion(RSA)during the first trimester of pregnancy,and to study the levels of E_(2),P,andβ-HCG for predicting their spontaneous abortion again.Methods:89 pregnant women with RSA during the first trimester of pregnancy were selected in study group,and 50 normal pregnant women without RSA during the first trimester of pregnancy were selected in control group between August 2017 and October 2020.The women in the study group were further divided into group A(32 cases with spontaneous abortion again)and group B(57 cases without spontaneous abortion again).The levels of E_(2),P,andβ-HCG of the women in these groups during the first trimester of pregnancy(4,6,8,10,and 12 gestational weeks)were detected.The differences of sex hormones levels of the women in these groups were analyzed,and the predictive values of the levels of E_(2),P,andβ-HCG of the pregnant women with RSA during different gestational weeks for their pregnancy outcomes were analyzed.Results:The levels of E_(2),P,andβ-HCG of the women in the study group during 4,6,8,10,and 12 gestational weeks were significantly lower than those of the women in the control group,and which of the women in group A were significantly lower than those of the women in group B(all P<0.05).The area under the curve(AUC)of the E_(2) level of women in the study group during 4,6,8,10,and 12 gestational weeks for predicting abortion of the women again were 0.743,0.755,0.748,0.769,and 0.748,respectively.The area under the curve(AUC)of the P level of women in the study group during 4,6,8,10,and 12 gestational weeks for predicting abortion of the women again were 0.857,0.852,0.707,0.884,and 0.730,respectively.The area under the curve(AUC)of the P level of women in the study group during 4,6,8,10,and 12 gestational weeks for predicting abortion of the women again were 0.617,0.777,0.919,0.900,and 0.904,respective

关 键 词：复发性流产再妊娠 孕早期 雌二醇 孕酮 Β-人绒毛膜促性腺激素 预测流产 

分 类 号：R714.21[医药卫生—妇产科学]