ICSI周期中卵母细胞滑面内质网聚集体异常与胚胎发育及妊娠结局  

Correlation between abnormal smooth endoplasmic reticulum congeries of oocyte of women in intracytoplasmic sperm injection cycle and their embryonic development and pregnancy outcomes

作　　者：王小飞 周燕 涂铵素 钟影 WANG Xiaofei;ZHOU Yan;TU Ansu;ZHONG Ying(Jinjiang Matrnal and Child Health Care Hospital,Chengdu,Sichuan Province,610016;Chengdu Xinan Gymecology Hos pital)

机构地区：[1]四川省成都市锦江区妇幼保健院,610016 [2]四川省成都西囡妇科医院

出　　处：《中国计划生育学杂志》2022年第6期1408-1411,共4页Chinese Journal of Family Planning

摘　　要：目的:研究卵母细胞滑面内质网聚集体(sERC)对胚胎发育及妊娠结局的影响。方法:回顾性收集2020年1月—2020年7月本院行卵胞浆内单精子显微注射(ICSI)助孕治疗的患者120例,根据卵母细胞内是否出现sERC分为sERC阳性组(52例)及sERC阴性组(68例),比较两组胚胎发育情况、临床结局以及活产婴儿的畸形情况。结果:两组获卵数、成熟卵率、受精率、优胚率以及种植率均未见差异(P>0.05),sERC阳性组囊胚形成率(23.1%)、临床妊娠率(38.5%)、活产率(28.9%)低于sERC阴性组(41.2%、57.4%、51.5%),流产率(19.2%)高于sERC阴性组(5.9%),活产婴儿发生多发畸形(6.7%)及心血管畸形(20.0%)高于sERC阴性组(0.0%、2.9%)(P<0.05)。结论:卵母细胞sERC异常对ICSI胚胎发育及妊娠结局有一定影响。Objective:To study the effects of smooth endoplasmic reticulum congeries(sERC)of oocyte of women in intracytoplasmic sperm injection(ICSI)cycle on their embryonic development and pregnancy outcomes.Methods:In this study,120 women with ICSI assisted reproduction from January 2020 to July 2020 were collected as the research objects retrospectively,and were divided into group A(52 cases with positive sERC)and group B(68 with negative sERC).The embryonic development,the clinical outcomes,and the deformity rate of live born infants were compared between the two groups.Results:There were no significant differences in the number of eggs obtained,the rates of the mature egg,the fertilization,the optimal embryo,and the embryo implantation of the women between the two groups(P>0.05).The rates of blastocyst formation(23.1%),the clinical pregnancy(38.5%),and the live birth(28.9%)of the women in group A were significantly lower than those(41.2%,57.4%,and 51.5%)of the women in group B,and the abortion rate(19.2%)of the women in group A was significantly higher than that(5.9%)of the women in group B.The incidences of multiple malformations(6.7%)and the cardiovascular malformations(20.0%)of the live birth newborns in group A were significantly higher than those(0.0%and 2.9%)of the live birth newborns in group B(all P<0.05).Conclusion:Abnormal sERC of oocytes of the women during ICSI has certain impact on their embryonic development and pregnancy outcomes.

关 键 词：卵胞浆内单精子显微注射 卵母细胞 滑面内质网聚集体 胚胎发育 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]