稀土上转换多功能复合材料的构建及生物应用进展  

Progress on construction and biological application of rare earth upconversion multifunctional nanocomposites

作　　者：徐蕴泽 尧雨斯 朱国庆[2] 汪志方 李春霞 XU Yun-ze;YAO Yu-si;ZHU Guo-qing;WANG Zhi-fang;LI Chun-xia(College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua 321004,China;Institute of Molecular Sciences and Engineering,Institute of Frontier and Interdisciplinary Science,Shandong University,Qingdao 266237,China)

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004 [2]山东大学前沿交叉科学青岛研究院分子科学与工程研究院,山东青岛266237

出　　处：《分子科学学报》2022年第1期12-27,共16页Journal of Molecular Science

基　　金：国家自然科学基金资助项目(51872263,52050077);泰山学者资助项目(ts20190911)。

摘　　要：镧系离子(Ln^(3+))掺杂的稀土上转换纳米材料在低能近红外光激发下可发射高能量的紫外、可见甚至近红外光,由于其独特的光学和化学性质,包括自荧光弱、对生物体光损伤小及组织穿透深度高等,稀土上转换纳米材料在生物医学领域的应用备受关注.在该综述中,主要介绍了本课题组在稀土上转换纳米发光材料的自组装、复合材料的构建及在肿瘤诊疗领域的相关工作,重点强调设计、合成多种刺激-响应型的多功能纳米诊疗平台,利用肿瘤微环境的特点(乏氧、偏酸性、富含H_(2)O_(2)和谷胱甘肽)和近红外光的独特优势,实现纳米材料在肿瘤部位的靶向蓄积、药物的选择性控制释放和协同肿瘤治疗(化疗、光动力治疗、光热治疗及免疫治疗等).Cancer is the second leading cause of death after cardiovascular disease.Traditional chemotherapy drugs have some problems,such as low drug utilization,high toxic and side effects,low therapeutic effect and lack of targeting.Therefore,it is the research direction to continuously develop new antitumor drug delivery systems so as to improve drug targeting and bioavailability,reduce toxic and side effects and improve therapeutic effect.In order to solve these problems,it is urgent to develop stimuli-responsive nanocarriers to realize the controlled release of drugs.In various external stimuli,light provides a good non-invasive control method for precise control of drug release at fixed points.Especially near-infrared(NIR)light-based multifunctional nanomaterials are a new kind of diagnostic and therapeutic agents,which are an important branch of biomedical functional materials,providing new opportunities for efficient tumors therapy.Lanthanide ions(Ln^(3+))doped rare earth up-conversion nanoparticles(UCNPs)can emit high-energy ultraviolet,visible even NIR light under low-energy NIR light excitation.UCNPs-based multifunctional nanomaterails have attracted great attention in the fields of materials science and biomedicine due to their unique optical and chemical properties.In this review,we mainly focus on our related studies about self-assembly of UCNPs,the fabrication of nanocomposites and tumor diagnosis and treatment.The design and synthesis of multiple stimuli-responsive nanocomposites had been highlighted.The aim is to harness the tumor microenvironment(hypoxia,acidic,rich H_(2)O_(2)and glutathione)and the unique advantages of NIR light to achieve targeted accumulation at tumor sites of nanomaterials,selectively controlled release of drugs as well as synergistic tumor treatments(chemotherapy,photodynamic therapy,photothermal therapy,immunotherapy,etc.).

关 键 词：镧系离子(Ln^(3+)) 稀土上转换 肿瘤微环境 肿瘤治疗 

分 类 号：O631[理学—高分子化学]