骨密度、血清前胶原蛋白Ⅲ水平与围绝经期女性心血管事件的关系研究  

The relationship between bone mineral density,serum procollagen Ⅲ level and cardiovascular events in perimenopausal women

作　　者：席爱萍[1] 李欣[2] 许岩丽 桂艳红 王珅 XI Ai-ping;LI Xin;XU Yan-li(Affiliated Hospital of Hebei University of Engineering,Handan 056002,China)

机构地区：[1]河北工程大学附属医院,河北邯郸056002 [2]河北省邯郸市第一医院 [3]河北工程大学医学院

出　　处：《中国实验诊断学》2022年第4期499-502,共4页Chinese Journal of Laboratory Diagnosis

基　　金：河北省卫健委重点课题(N20210936);河北省医学科学研究课题计划(20220036)。

摘　　要：目的 探讨骨密度、血清前胶原蛋白Ⅲ(PCⅢ)水平与围绝经期女性心血管事件(CVE)的关系。方法 回顾性分析2020年5月至2021年5月河北工程大学附属医院接诊的围绝经期女性80例的临床资料,根据是否发生CVE将围绝经期女性分为CVE组(25例)和无CVE组(55例)。收集两组患者的基础资料[年龄、体质指数(BMI)、吸烟史、饮酒史、高脂血症史、高胰岛素血症史、低骨密度、糖尿病史、高血压史]和实验室指标[前胶原蛋白Ⅲ(PCⅢ)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)];以ROC曲线分析PCⅢ预测围绝经期女性CVE的价值;采取非条件Logistic逐步回归分析围绝经期女性发生CVE的危险因素。结果 CVE组有高胰岛素血症史、低骨密度、糖尿病史、高血压史的人数显著多于无CVE组,CVE组的PCⅢ水平显著高于无CVE组,差异有统计学意义(P<0.05);经ROC曲线分析,围绝经期女性PCⅢ≥159.577μg/L是预测发生CVE的最佳截断值(P<0.05);Logistic逐步回归分析显示高胰岛素血症史、低骨密度、糖尿病史、高血压史、PCⅢ≥159.577μg/L是围绝经期女性发生CVE的危险因素(P<0.05)。结论高胰岛素血症史、低骨密度、糖尿病史、高血压史、PCⅢ≥159.577μg/L是围绝经期女性发生CVE的危险因素。Objective To investigate the relationship between bone mineral density,serum procollagen Ⅲ(PC Ⅲ)level and cardiovascular events(CVE)in perimenopausal women.Methods The clinical data of 80perimenopausal women admitted to our hospital from May 2020to May 2021were retrospectively analyzed.According to the incidence of CVE,perimenopausal women were divided into CVE group(25cases)and non-CVE group(55cases).Two groups of patients on the basis of information collection[age,body mass index(BMI),smoking history,drinking history,history of hyperlipidemia,high insulin hematic disease history,history of low bone mineral density,history of diabetes,high blood pressure]and laboratory index[former collagenⅢ(PC Ⅲ),triglyceride(TG),low density lipoprotein cholesterol(LDLC),high density lipoprotein cholesterol(HDL-C)];ROC curve was used to analyze the value of PC Ⅲ in predicting CVE in perimenopausal women.The risk factors of CVE in perimenopausal women were determined by stepwise Logistic regression analysis.Results The number of patients with a history of hyperinsulinemia,low bone mineral density,diabetes and hypertension in CVE group was significantly higher than that in non-CVE group,and the level of PC Ⅲin CVE group was significantly higher than that in non-CVE group,the difference was statistically significant(P<0.05).According to ROC analysis,PC Ⅲ ≥159.577μg/L was the best cut-off value for predicting the occurrence of CVE in perimenopausal women(P<0.05).Step-to-step Logistic regression analysis showed that history of hyperinsulinemia,low bone mineral density,history of diabetes,history of hypertension and PC Ⅲ≥159.577μg/L were risk factors for CVE in perimenopausal women(P<0.05).Conclusion History of hyperinsulinemia,low bone mineral density,history of diabetes mellitus,history of hypertension and PCⅢ≥159.577μg/L were risk factors for CVE in perimenopausal women.

关 键 词：围绝经期 心血管事件 骨密度 前胶原蛋白Ⅲ 危险因素 

分 类 号：R540.4[医药卫生—心血管疾病] R711.75[医药卫生—内科学]