小儿肺炎支原体感染临床特征及危险因素分析  

Investigation on clinical status and risk factors of Mycoplasma pneumoniae in children

作　　者：张丽侠[1] 李荣利[1] 李萍[1] 史文清 郭慧 马涛[1] ZHANG Li-xia;LI Rong-li;LI Ping;SHI Wen-qing;GUO Hui;MA Tao(Bozhou Peoples Hospital,Bozhou 236800,Anhui,China)

机构地区：[1]安徽亳州市人民医院,安徽亳州236800

出　　处：《中国病原生物学杂志》2022年第3期314-316,共3页Journal of Pathogen Biology

摘　　要：目的 调查小儿肺炎支原体临床特征及危险因素,指导肺炎支原体感染的预防与治疗。方法 收集113例小儿肺炎支原体感染患儿临床资料及临床指标;采集患儿血液样本,用呼吸道病原体谱抗体IgM检测试剂盒检测肺炎支原体,并对其耐药性进行分析;对数据进行统计学分析,分析差异显著性及感染相关性。结果 小儿肺炎支原体感染的临床特征表现为高热或超高热、热程在7 d以内、肺部细湿啰音、C反应蛋白(CRP)升高、阵发性连声咳嗽、白细胞(WBC)升高、X线胸片肺部小斑点状模糊影。影响患儿肺炎支原体感染发生的危险因素包括性别、发病季节、居住环境、抗生素使用时间、低补体态以及流行接触史(P<0.05)。肺炎支原体对罗红霉素、阿奇霉素、红霉素、克拉霉素、乙酰螺旋霉素、克林霉素的耐药率分别为67.26%、21.24%、69.03%、27.43%、41.59%和46.02%。肺炎支原体对临床常用的大环内酯类抗菌药物均产生了一定程度耐药性,但对司帕沙星仍敏感。结论 积极监测患儿肺炎支原体感染临床情况及危险因素,可以有效预防临床感染发生。Objective Clinical status and risk factors of Mycoplasma pneumoniae in children were investigated to provide guidance for prevention and treatment of clinical anti-infection.Methods Clinical data and clinical indicators of 113 children with M.pneumoniae infection were collected.Children’s blood samples were collected,and M.pneumoniae was detected with IgM detection kit,and its drug resistance was analyzed.The variation was analyzed by sequencing.Statistical analysis was carried out for the data to analyze the significance of the difference and the correlation of infection.Results The clinical features of M.pneumoniae in children were high or ultra-high fever,heat range within 7 days,lung fine and moist rayed,C-reactive protein(CRP) increased,paroxysmal continuous cough,leukocyte(WBC) increased,X-ray chest X-ray lung small speck fuzzy shadow(P<0.05).The risk factors affecting the incidence of M.pneumoniae infection in children included gender,season of onset,living environment,duration of antibiotic use,hypotonic posture and epidemic exposure history(P<0.05).The drug resistance rates of M.pneumoniae to roxithromycin,azithromycin,erythromycin,clarithromycin,acetylspiramycin and clindamycin were 67.26%,21.24%,69.03%,27.43%,41.59% and 46.02%,respectively.M.pneumoniae developed a degree of resistance to macrolide antibiotics commonly used in clinical treatment,but was still sensitive to sparfloxacin.Conclusion Active monitoring of clinical status and risk factors of My.pneumoniae infection in children can effectively prevent clinical infection.

关 键 词：患儿 肺炎支原体 临床特点 危险因素 耐药性 

分 类 号：R375[医药卫生—病原生物学]