胰激肽原酶辅助治疗对2型糖尿病肾病合并高血压患者血压水平、肾动脉血流动力学及氧化应激水平的影响  

Effects of pancreatic kinkinase adjuvant therapy on blood pressure,renal arterial hemodynamics and oxidative stress in patients with type 2 diabetic nephropathy complicated with hypertension

作　　者：郭静 叶青[2] 徐俊涛 华中阁 Guo Jing;Ye Qing;Xu Jun-tao;Hua Zhong-ge(Department of Endocrinology,Xichuan People's Hospital,Xichuan 474450,Henan,China;Department of Rheumatology,Shiyan People's Hospital,Shiyan 442000,Hubei,China)

机构地区：[1]淅川县人民医院内分泌科,河南淅川474450 [2]十堰市人民医院风湿免疫科,湖北十堰442000

出　　处：《四川生理科学杂志》2022年第5期826-828,889,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:分析2型糖尿病肾病合并高血压患者应用胰激肽原酶辅助卡维地洛对血压水平、肾动脉血流动力学及氧化应激水平的影响。方法:以2019年3月至2020年9月期间我院收治的113例2型糖尿病肾病合并高血压患者作为研究对象,采用摸球法分组。两组患者均接受常规治疗,在此基础上对照组56例给予卡维地洛治疗,研究组57例联合胰激肽原酶注射液治疗。3个月后,对比两组患者血压水平、肾动脉血流动力学指标、氧化应激指标、不良反应。结果:治疗后,研究组患者血管舒张压、收缩压水平均低于对照组(P<0.05);患者阻力指数水平低于对照组,肾动脉收缩期血流峰值速度、舒张末期血流速度水平均高于对照组(P<0.05);患者超氧化物歧化酶、谷胱甘肽过氧化物酶水平均高于对照组,丙二醛水平低于对照组(P<0.05);两组患者不良反应比较无明显差异(P>0.05)。结论:胰激肽原酶联合辅助治疗2型糖尿病肾病合并高血压患者效果确切,能够控制血压水平,改善肾动脉血液循环及氧化应激反应,且安全性较高,临床推广价值较高。Objective:To analyze the effects of pancreatic kinkinase combined with carvedilol on blood pressure,renal arterial hemodynamics and oxidative stress in patients with type 2 diabetic nephropathy complicated with hypertension.Methods:From March 2019 to September 2020,113 patients with type 2 diabetic nephropathy and hypertension who were admitted to our hospital were selected as the research objects,and were divided into groups by touching the ball method.Both groups of patients received conventional treatment.On this basis,56 cases in the control group were treated with carvedilol,and 57 cases in the study group were treated with kallikrein injection.After 3 months,blood pressure level,renal arterial hemodynamics index,oxidative stress index and adverse reactions were compared between the two groups.Results:After treatment,the levels of diastolic blood pressure and systolic blood pressure in the study group were lower than those in the control group(P<0.05).,end-diastolic blood flow velocity levels were higher than those in the control group(P<0.05);after treatment,the levels of superoxide dismutase and glutathione peroxidase in the study group were higher than those in the control group,and the level of malondialdehyde was lower compared with the control group(P<0.05);there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Pancreatic kinkinase is effective in the adjuvant treatment of type 2 diabetic nephropathy complicated with hypertension,which can control blood pressure level,improve renal arterial blood circulation and oxidative stress response,with high safety and high clinical promotion value.

关 键 词：胰激肽原酶 2型糖尿病肾病 高血压 肾动脉血流动力学 

分 类 号：R54[医药卫生—心血管疾病]