灵芝三萜的生物活性及潜在应用研究  

Bioactivity and potential application of triterpenoids from Ganoderma lucidum

作　　者：马传贵 张志秀 肖宝[2] 孙思胜[3] Ma Chuangui;Zhang Zhixiu;Xiao bao;Sun Sisheng(Beijing Jingcheng Biological Technology Co.Ltd.,Beijing 102600,China;Chinese Academy of Medical Sciences&Peking Union Medical College Institute of Biomedical Engineering,Tianjin 300192,China;College of Food andPharmacy,Xuchang University/Key Laboratory of Biomarker Based Rapid-detection Technology forFood Safety of Henan Province,Xuchang,Henan 461000,China)

机构地区：[1]北京京诚生物科技有限公司,北京102600 [2]中国医学科学院北京协和医学院生物医学工程研究所,天津300192 [3]许昌学院食品与药学院/河南省食品安全生物标识快检技术重点实验室,河南许昌461000

出　　处：《食药用菌》2022年第3期197-201,共5页Edible and Medicinal Mushrooms

基　　金：河南省科技厅科技攻关项目(192102310441)。

摘　　要：灵芝作为重要的药用真菌,其主要生物活性成分包括多糖、糖肽及三萜类化合物等,其中,灵芝三萜类化合物系高度氧化的羊毛甾烷衍生物,表现出强大且独特的生物活性及药理价值,目前灵芝三萜含量已成为《美国药典(United States Pharmacopoeia)》对灵芝质量的评价标准。综述目前关于灵芝三萜生物活性的研究成果,包括细胞毒性和抗肿瘤活性、抗氧化和保肝活性、神经保护作用、助眠特性、抗糖尿病活性等;概述灵芝三萜在功能性食品和保健品开发中的潜在应用价值,并探讨其未来的研究方向。Ganoderma lucidum is an important medicinal mushroom,contains polysaccharides,glycopeptides,triterpenoids and other bioactive components.Ganoderma triterpenoids belong to highly oxidized lanosterol derivatives,which show strong and unique bioactivity and pharmacological value.At present,the content of ganoderma triterpenoids has become the evaluation standard of G.lucidum quality in the United States Pharmacopoeia.This paper reviews the current research results on the biological activities of ganoderma triterpenoids,including cytotoxicity and anti-tumor activity,antioxidant and hepatoprotective activity,neuroprotective effect,hypnotic properties,anti-diabetes activity,etc.Meanwhile,this paper summarizes the potential application of ganoderma triterpenoids in the development of functional food and health products,and discusses its future research direction.

关 键 词：灵芝三萜 生物活性 抗肿瘤 细胞毒性 神经保护 保健品开发 

分 类 号：S646[农业科学—蔬菜学]