氧化应激诱导勃起功能障碍机制的研究进展  

Advances in Study of Oxidative Stress-induced Erectile Dysfunction

作　　者：牛阳九 杨培 牛立盼 刘凤霞 NIU Yangjiu;YANG Pei;NIU Lipan;LIU Fengxia(Department of Human Anatomy,Basic Medical College,Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学基础医学院人体解剖学教研室,乌鲁木齐830011

出　　处：《医学综述》2022年第10期1890-1895,共6页Medical Recapitulate

基　　金：国家自然科学基金(81860781);新疆维吾尔自治区重点学科建设项目(新教财〔2018〕180号)。

摘　　要：勃起功能障碍(ED)是男性的常见病,其发病机制复杂且受多种因素影响,如炎症反应、氧化应激、血管及血管活性物质改变等。目前ED的主要治疗方法是口服磷酸二酯酶Ⅴ型抑制剂,该类药物虽可有效改善患者的勃起功能,但部分患者会发生明显的不良反应。氧化应激在ED的发生发展中扮演重要角色,且抗氧化治疗有利于勃起功能的恢复。但氧化应激在ED中的作用机制尚不明确,因此探究氧化应激与ED的关系,梳理其作用机制,可系统挖掘该病的科学内涵,为ED的深入研究和诊疗提供新方向。Erectile dysfunction(ED)is a common disease in men,and its pathogenesis is complex and influenced by a variety of factors,such as inflammatory response,oxidative stress,vascular and vasoactive substance alterations.Currently,the main treatment for ED is oral phosphodiesterase type V inhibitors,which are effective in improving erectile function,but can cause significant adverse effects in some patients.Oxidative stress plays an important role in the development of ED,and antioxidant therapy is beneficial for the restoration of erectile function.However,the mechanism of oxidative stress in ED is still unclear,so investigating their relationship and sorting out its mechanism of action can systematically explore the scientific connotation of the disease and provide new directions for the in-depth research and diagnosis and treatment of ED.

关 键 词：勃起功能障碍 氧化应激 发病机制 

分 类 号：R697[医药卫生—泌尿科学]