基于免疫浸润特征从“浊邪化热,虚火灼脉”论治糖尿病大血管损伤  

Treatment of Diabetic Macrovascular Injury based on Immune Infiltration Characteristics with the Theory of“Pathogenic Turbid Transforms into Heat,Deficiency Fire Scorching Vessels”

作　　者：关明丹 王庆峰 杨宇峰[1] 石岩[1] GUAN Mingdan;WANG Qingfeng;YANG Yufeng;SHI Yan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847)

机构地区：[1]辽宁中医药大学,辽宁省沈阳市110847

出　　处：《中医杂志》2022年第9期825-829,共5页Journal of Traditional Chinese Medicine

基　　金：辽宁省“兴辽英才计划”青年拔尖人才资助项目(XLYC1807145);辽宁省人社厅百千万人才资助项目(20200512)。

摘　　要：基于免疫浸润特征的现代研究,以浊邪为切入点,探讨糖尿病大血管损伤的病机演变过程,为其辨治提供新思路。指出脾胃损伤-酿生浊邪乃糖尿病大血管损伤的发病基础,“浊邪化热,虚火灼脉”为核心病机。临床以健脾化浊、滋阴泻火、痰瘀同治为其核心治则治法。Based on the immune infiltration characteristics found in the modern researches,this paper explored the evolution of the pathogenesis of diabetic macrovascular injury(DMI)by taking pathogenic turbid as the entry point,so as to provide new ideas for the syndrome differentiation and treatment of DMI.It is pointed out that pathogenic turbid induced by spleen and stomach injury is the basic pathogenesis of DMI,and“pathogenic turbid transforming into heat,and deficiency fire scorching vessels”is the core pathogenesis.In clinical practice,the core therapeutic principles and methods are to fortify the spleen and remove turbidity,enrich yin and drain fire,and treat the phlegm and stasis simultaneously.

关 键 词：糖尿病 血管损伤 糖代谢 脂代谢 免疫浸润 炎症反应 浊邪 

分 类 号：R273[医药卫生—中西医结合]