我国38家采供血机构新冠肺炎康复者恢复期血浆采集制备供应实践经验  

Practical Experience of COVID-19 Convalescent Plasma Collection,Preparation and Distribution by 38 Blood Stations in China

作　　者：易星 袁晓华[2] 白林 丛培芳 王媛 李丽[6] 蔡红军[7] 张小霞 张洁烨 鲍琳 甄晓峰 张剑 成宁[13] 陈阳[14] 郭晓婕 王慧 付竹筠 杨培[18] 王振兴[19] 冼志莲 王林[21] 邱艳[22] YI Xing;YUAN Xiao-hua;BAI Lin(Changsha Blood Center,Changsha 410026)

机构地区：[1]长沙血液中心,410026 [2]乌鲁木齐市血液中心 [3]太原市血液中心 [4]青岛市中心血站 [5]河南省红十字血液中心 [6]淮安市中心血站 [7]泰州市中心血站 [8]庆阳市中心血站 [9]无锡市红十字中心血站 [10]宜春市中心血站 [11]邢台市中心血站 [12]盐城市中心血站 [13]内蒙古自治区血液中心 [14]辽宁省血液中心 [15]安徽省血液中心 [16]扬州市中心血站 [17]九江市中心血站 [18]重庆市血液中心 [19]东莞市中心血站 [20]湛江市中心血站 [21]海南省血液中心 [22]北京红十字血液中心

出　　处：《临床输血与检验》2022年第3期285-291,共7页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的总结用于新冠肺炎临床预防治疗的新冠康复者恢复期血浆(简称新冠血浆,COVID-19 convalescent plasma,CCP)采集生产制备的经验。方法采用问卷调查的方式,对全国72家省市采供血机构新冠血浆采集工作的情况进行调查,内容包括采集、检测、制备、供应与质量控制等环节。结果有61家采供血机构开展了新冠血浆采集相关工作,38家采供血机构自愿回答全部或部分问题。新冠血浆的采集主要以已有献血屋或临时设置设施地点为主;其中30家采供血机构共采集新冠血浆1359.8单位;采集的新冠血浆ABO血型A∶B∶O∶AB比为2.2∶2.2∶1.8∶1;37家机构分享了采集到的新冠血浆加工制备情况;各地新冠血浆质控标准,血浆储存和不合格新冠血浆的处置以及临床供应方式根据自身情况制定且存在差异。结论各地在利用现有资源完成新冠血浆采集制备和质量控制基础上,有必要建立新冠血浆采集和制备等的统一标准和指导原则,为临床治疗效果的评价和临床研究提供统一的新冠血浆制品种类。Objective To explore the experience of the collection,preparation and distribution of the COVID-19 convalescent plasma(CCP)for the prevention and control of the COVID-19 pandemic.Methods A survey was conducted by answering a questionnaires on the collection,testing,preparation,distribution and quality control of CCP by 72 blood stations across the country.Results 61 blood stations implemented CCP collection and 38 blood stations sharing the data.The CCP collection was mainly based on existing blood donation facilities or temporary facilities.30 blood stations collected 1359.8 units(200 mL/unit)CCP.The ABO blood group A∶B∶O∶AB ratio of CCP was 2.2∶2.2∶1.8∶1.37 blood stations provided the collected CCP process methods.The preparation procedure,and the local quality control standards,CCP storage,disposal of substandard products,and clinical supply strategies have been varied due to each blood stations’own conditions.Conclusion Although the regional blood stations accomplished the CCP collection and supply based on their existence resources,it is necessary to set up unified criteria and guideline for specific collection and preparation strategies and provide the qualified CCP for clinical trial evaluation.

关 键 词：新冠肺炎 采供血机构 问卷调查 新冠血浆采集 成分血制备 新冠血浆质量标准 新冠血浆供应 

分 类 号：R457[医药卫生—治疗学]