沙丁胺醇预先吸入给药对支原体肺炎患儿纤支镜灌洗术中气道不良反应发生情况的影响  

Effect of pre-inhalation administration of salbutamol on the occurrence of airway adverse reactions during fiberbronchoscopic lavage in children with Mycoplasma pneumonia

作　　者：陈倩 胡丹 CHEN Qian;HU Dan(Ankang Central Hospital,Ankang 725000,China)

机构地区：[1]安康市中心医院,陕西安康725000

出　　处：《临床医学研究与实践》2022年第18期72-75,共4页Clinical Research and Practice

摘　　要：目的探究沙丁胺醇预先吸入给药对支原体肺炎患儿纤支镜灌洗术中气道不良反应发生情况的影响。方法选取2018年3月至2020年3月本院收治的120例行支原体肺炎纤支镜灌洗术的患儿为本次研究对象,以数字随机法将其分为参照组(n=60)和研究组(n=60)。两组患儿均接受纤支镜灌洗术治疗,参照组术前未给予预先给药处理,研究组术前给予沙丁胺醇预先吸入给药。比较两组患儿的手术及苏醒情况(手术时间、丙泊酚用量、苏醒时间)、术中呛咳次数、纤支镜灌洗暂停次数、呼吸功能指标(呼吸频率、动态顺应性、氧合指数)、炎症因子指标[白细胞计数(WBC)、降钙素原(PCT)、高敏C反应蛋白(hs-CPR)]、血气指标[动脉血氧分压(PaO_(2))、血氧饱和度(SpO_(2))、动脉血二氧化碳分压(PaCO_(2))]。结果研究组患儿的手术时间、苏醒时间显著短于参照组,丙泊酚用量显著少于参照组,差异具有统计学意义(P<0.05)。研究组患儿术中呛咳次数、纤支镜灌洗暂停次数均显著少于参照组,差异具有统计学意义(P<0.05)。术后24 h,研究组患儿呼吸频率显著低于参照组,动态顺应性、氧合指数显著高于参照组,差异具统计学意义(P<0.05)。术后24 h,研究组患儿的WBC、PCT、hs-CPR水平均显著低于参照组,差异具统计学意义(P<0.05)。术后24 h,研究组患儿的PaO2、SpO2显著高于参照组,PaCO_(2)显著低于参照组,差异具统计学意义(P<0.05)。结论纤支镜灌洗术前开展沙丁胺醇预先吸入给药预处理可有效预防支原体肺炎患儿纤支镜灌洗术中的气道不良反应,并可改善患儿的呼吸功能、血气指标,减轻炎症反应,值得临床推广应用。Objective To investigate the effect of pre-inhalation administration of salbutamol on the occurrence of airway adverse reactions during fiberbronchoscopic lavage in children with Mycoplasma pneumonia.Methods A total of 120 children with Mycoplasma pneumonia admitted in our hospital from March 2018 to March 2020 and treated by fiberbronchoscopic lavage were selected as the research objects.The children were divided into reference group(n=60)and study group(n=60)by digital random method.Both groups were treated with fiberbronchoscopic lavage,the reference group was not given pre-administration treatment before operation,and the study group was given pre-inhalation administration of salbutamol before operation.The operation and recovery(operation time,dosage of propofol,recovery time),the times of choking and suspension of fiberbronchoscopic lavage during operation,respiratory function indexes(respiratory rate,dynamic compliance,oxygenation index),inflammatory factors indexes[white blood cell count(WBC),procalcitonin(PCT)and high sensitive C-reactive protein(hs-CRP)]and blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),blood oxygen saturation(SpO_(2)),partial pressure of arterial carbon dioxide(PaCO_(2))]were compared between the two groups.Results The operation time and recovery time in the study group were significantly shorter than those in the reference group,the dosage of propofol was significantly less than that in the reference group,and the differences were statistically significant(P<0.05).The times of choking and suspension of fiberbronchoscopic lavage during operation in the study group were significantly less than those in the reference group,and the differences were statistically significant(P<0.05).At 24 h after operation,the respiratory rate in the study group was significantly lower than that in the reference group,the dynamic compliance and oxygenation index were significantly higher than those in the reference group,and the differences were statistically significant(P<0.05).At 24 h aft

关 键 词：沙丁胺醇预先吸入 支原体肺炎 纤支镜灌洗术 气道不良反应 呼吸功能 血气指标 

分 类 号：R725.6[医药卫生—儿科]