BNCT中子源的研发现况与展望  

Status and outlook:Research and development on the neutron source for BNCT

作　　者：傅世年[1,2,3] 梁天骄 陈和生[1,2,3] Shinian Fu;Tianjiao Liang;Hesheng Chen(Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;Spallation Neutron Source Science Center,Dongguan 523803,China;College of Nuclear Science and Technology,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院高能物理研究所,北京100049 [2]散裂中子源科学中心,东莞523803 [3]中国科学院大学核科学与技术学院,北京100049

出　　处：《科学通报》2022年第14期1471-1478,共8页Chinese Science Bulletin

基　　金：珠江人才计划(2017ZT07S225)资助。

摘　　要：硼中子俘获疗法(boron neutron capture therapy,BNCT)治疗癌症是一种典型的二元疗法,它既需要高品质的中子束,又需要高靶向性的含硼药物,两者缺一不可、密切配合,方可对肿瘤实现细胞级精准的靶向杀伤.BNCT治疗方法显著的优越性的背后,是对中子源和载硼药物特性的很高要求.含硼药物研究涉及多学科,包括放射学、化学、医学、药学、生物学和物理学等.本文主要讨论BNCT中子源的问题.首先,介绍BNCT对中子束特性要求的国际标准,回顾几十年来BNCT中子源发展的困难所在;然后,展现近年来加速器中子源异军突起、开创BNCT新未来的前景,明确研发中的核心技术;最后,报告我国在此领域前沿研究的最新成果及其发展展望.Boron neutron capture therapy(BNCT)is regarded as a revolutionary means for high-accuracy cancer therapy with celllevel selectivity.It has unique therapeutic effects for some malignancies,such as glioblastoma multiforme,melanoma,recurrent head and neck malignancy.It can also be used for cancer treatment of deep organ,such as liver and lung.Even though its principle was proposed about 80 years ago,it has never been utilized in routine clinic therapy in hospital until 2020.BNCT,as a binary therapeutic method,greatly depends on both high-quality neutron beam and highly targetselective boron drug.Tumor killing in cell-level accuracy can be achieved only when the two elements work together and collaborate closely.To realize such therapeutic effect,BNCT sets high requirement on both neutron source and boron drug.The research on boron drug is related with multi-disciplines,such as chemistry,biology,medicine,radiology,pharmacy and physics.This article focuses on the neutron source for BNCT.Commonly,there are two types of BNCT neutron sources:reactor-based neutron source and accelerator-based neutron source.Up to now,almost all clinic trials of BNCT therapy were performed with the former.Due to limited resources of reactor neutron source,only less than 2000 cases BNCT treatments have been carried out in the world since BNCT method was invented.Thanks to the intense beam proton accelerator development,accelerator based neutron source can provide better beam quality,and especially important it can be installed in a hospital environment,which is essential for wide-range application of BNCT.In accelerator-based BNCT field,China has a sound base owing to more than 20 years research and development in high intensity neutron source for spallation neutron source and accelerator-driven subcritical system.It is meaningful work to transfer the related technology to accelerator-based BNCT(AB-BNCT).In this paper we will firstly introduce the demand for neutron beam specification recommended by IAEA.Then the difficulties in BNCT slow d

关 键 词：硼中子俘获疗法(BNCT) 强流质子加速器 中子源 载硼靶向药物 

分 类 号：O571.53[理学—粒子物理与原子核物理] R730.5[理学—物理]