蛋白质巯基修饰与心血管重构  

Protein sulfhydryl modification and cardiovascular remodeling

作　　者：赵爽 唐欣 谢利平[2] 季勇[1,2] ZHAO Shuang;TANG Xin;XIE LiPing;JI Yong(Key Laboratory of Cardiovascular and Cerebrovascular Medicine,Nanjing Medical University,Nanjing 210000,China;Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]江苏省心脑血管药物重点实验室,南京医科大学,南京210000 [2]江苏省心血管病转化医学协同创新中心,南京医科大学,南京210000

出　　处：《中国科学：生命科学》2022年第5期633-645,共13页Scientia Sinica(Vitae)

摘　　要：细胞中蛋白质功能的调节依赖于发生在特定氨基酸上的翻译后修饰(post-translational modification,PTM),包括磷酸化、乙酰化、甲基化、泛素化等.近年来,蛋白质半胱氨酸巯基发生的多种翻译后修饰受到广泛关注,其中气体信号分子一氧化氮(nitric oxide,NO)和硫化氢(hydrogen sulfide,H2S)分别介导的蛋白质巯基亚硝基化修饰(S-nitrosylation,SNO)和蛋白质巯基硫化修饰(S-sulfhydration,SSH)是目前的研究热点,同时还包括棕榈酰化(Spalmitoylation)、谷胱甘肽化(S-glutathionylation)以及磺酸化(S-sulfonation)修饰等.本文将结合本课题组的长期工作和其他团队的研究成果,重点讨论蛋白质巯基亚硝基化修饰和巯基硫化修饰在心血管重构中的作用.The function of proteins is largely regulated by the post-translational modifications occurring on the specific amino acids,including phosphorylation,acetylation,methylation,and ubiquitination.Recently,the post-translational modifications occurring on the sulfhydryl(-SH)of cysteine residues in proteins have received widespread attention.Among them,S-nitrosylation mediated by nitric oxide(NO)and S-sulfhydration mediated by hydrogen sulfide have become the hotspots of the research field,as well as Spalmitoylation,S-glutathionylation,and S-sulfonation.This article reviews the role of S-nitrosylation and S-sulfhydration in cardiovascular remodeling based on findings of our and other groups.

关 键 词：巯基亚硝基化修饰 巯基硫化修饰 一氧化氮 硫化氢 心血管重构 

分 类 号：R54[医药卫生—心血管疾病]