补体介导的炎症免疫功能紊乱在高血压及其靶器官损伤中的作用  

The role of complement pathway-mediated inflammation and immune regulation in the development of hypertension and related target organ damage

作　　者：阮承超[1] 高平进[1] RUAN ChengChao;GAO PingJin(Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院,上海市高血压研究所,上海200025

出　　处：《中国科学：生命科学》2022年第5期732-739,共8页Scientia Sinica(Vitae)

摘　　要：高血压是导致心脑血管疾病的首要危险因素,但其发病机制尚不清楚.近年来研究表明,大量的炎症免疫细胞激活参与高血压发生发展的全过程,提示慢性低度的炎症免疫诱导了血管损伤及其并发症的发生.补体途径作为免疫系统的重要调节因子,其在调节炎症反应,招募免疫细胞,分泌调节因子等过程中都起着重要的调控作用.补体途径的异常激活和补体分子的过量表达参与高血压相关心血管疾病的调控过程.本文综述了补体途径激活参与高血压靶器官损伤调节的研究进展,以期为心血管免疫学研究走向临床拓展思路.Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases.However,the molecular and pathological mechanism of hypertension remains unclear.Recent studies suggest that immune cell activation is involved in the development of hypertension,and chronic low-grade inflammation induces vascular dysfunction and related diseases.The complement pathway,as an important regulator of the immune system,plays a critical role in recruiting immune cells,regulating inflammation and inflammatory factors release.Abnormal activation of complement pathway and up-regulation of complement molecules are involved in the process of hypertension-related cardiovascular diseases.We herein mainly review the role of complement pathway in hypertension and related target organ damage,and propose a potential target for translational research in cardiovascular immunology.

关 键 词：高血压 补体途径 炎症免疫 

分 类 号：R544.1[医药卫生—心血管疾病]