钠尿肽受体C与心血管疾病研究进展  

Research progress in natriuretic peptide receptor C and cardiovascular disease

作　　者：邵帅 李晓东[1] 王继光[1] SHAO Shuai;LI XiaoDong;Wang JiGuang(Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院,上海市高血压研究所,上海200025

出　　处：《中国科学：生命科学》2022年第5期760-766,共7页Scientia Sinica(Vitae)

摘　　要：钠尿肽是调节机体水盐平衡以及维持心血管等器官功能稳态的一组多肽,包括心房钠尿肽(atrial natriuretic peptide,ANP)、脑钠肽(brain natriuretic peptide,BNP)和C型钠尿肽(C-Type natriuretic peptide,CNP)等,均可与钠尿肽受体C(natriuretic peptide receptor C,NPR-C)结合.传统观点认为NPR-C具有清除并降解钠尿肽的作用,然而越来越多的证据表明,NPR-C胞内结构域与抑制性G蛋白(inhibitory G protein,Gi)偶联介导许多生物学效应,参与调控高血压、动脉粥样硬化、冠心病、心律失常、肺动脉高压、心功能不全等多种心血管疾病.本文将重点阐述NPR-C及其相关信号通路在高血压等心血管疾病中的研究进展.Natriuretic peptide(NP)system includes a group of peptides that regulate the balance of water and salt and maintain functional homeostasis of organs of the cardiovascular and several other systems.It includes atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP)and C-type natriuretic peptide(CNP),which can bind to natriuretic peptide receptor C(NPR-C).NPR-C has been traditionally considered a NP clearance receptor responsible for natriuretic peptides degradation.However,there is increasing evidence that the intracellular domain of NPR-C is coupled to inhibitory G protein(Gi)which mediates many biological effects and participates in the pathophysiology of hypertension,atherosclerosis,coronary heart disease,arrhythmia,pulmonary hypertension,cardiac insufficiency and so on.This review focuses on the research progress in NPR-C and its related signaling pathways in hypertension and other cardiovascular diseases.

关 键 词：钠尿肽受体C 钠尿肽 高血压 血管平滑肌细胞 心肌纤维化 

分 类 号：R54[医药卫生—心血管疾病]