肺动脉去神经术治疗肺动脉高压研究进展  

Update on pulmonary artery denervation for pulmonary hypertension

作　　者：张航[1] 陈绍良[1] ZHANG Hang;CHEN ShaoLiang(Nanjing First Hospital Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属南京医院,南京210029

出　　处：《中国科学：生命科学》2022年第5期767-772,共6页Scientia Sinica(Vitae)

摘　　要：交感神经过度激活在肺动脉高压(pulmonary arterial hypertension, PAH)的进展中起着重要作用.肺动脉去神经术(pulmonary artery denervation, PADN)是最近提出的利用10个电极的消融导管治疗PAH的介入方法.本综述介绍了肺动脉交感神经的定位, PADN的关键步骤,以及目前在PAH或混合型毛细管后和前性肺动脉高压(combined pre-capillary and post-capillary PH, Cpc-PH)患者的临床试验结果.Sympathetic hyperactivation plays an important role in the progression of pulmonary hypertension. Pulmonary artery denervation(PADN) is a promising interventional method for pulmonary arterial hypertension(PAH) treatment using 10-electrode ablation catheter. This review describes the location of the pulmonary sympathetic nerve, the key steps of PADN, and clinical trial outcomes in patients with the first category of PAH or combined pre-capillary and post-capillary pulmonary hypertension.

关 键 词：肺动脉高压 交感神经 肺动脉去神经术 消融 10个电极的消融导管 临床试验 

分 类 号：R544.1[医药卫生—心血管疾病]