纤维蛋白原与白蛋白比值对慢阻肺患者急性加重风险的预测价值分析  

Predictive value of fibrinogen to albumin ratio for acute exacerbation risk in patients with chronic obstructive pulmonary disease

作　　者：赵静[1] 杨婷[1] 杜小琴[1] 王亚梅 牛彩云 Zhao Jing;Yang Ting;Du Xiaoqin;Wang Yamei;Niu Caiyun(The Fifth Affiliated Hospital of Xinjiang Medical University,Xinjiang 830011)

机构地区：[1]新疆医科大学第五附属医院,新疆830011

出　　处：《首都食品与医药》2022年第11期26-28,共3页Capital Food Medicine

摘　　要：目的探讨纤维蛋白原(FIB)与白蛋白(ALB)比值(FAR)对慢性阻塞性肺疾病(COPD)患者急性加重风险的预测价值.方法选取2019年8月-2020年12月新疆医科大学第五附属医院收治并确诊的95例COPD患者作为研究对象,根据出院后1年内有无再发急性加重住院分为非加重组(51例)和加重组(44例).采用全自动血凝仪检测患者入院时血清FIB水平,全自动生化分析仪检测患者血清ALB水平,并计算FAR;采用酶联免疫吸附法检测血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平.采用Pearson相关分析探讨FAR与CRP、IL-6、TNF-α的相关性,ROC曲线评价FAR对COPD患者急性加重风险的预测价值.结果加重组COPD患者FAR、CRP、IL-6、TNF-α均高于非加重组(P<0.05).Pearson相关分析结果显示,COPD患者FAR与血清CRP、IL-6、TNF-α均呈正相关(P<0.05).ROC曲线分析结果显示,FAR预测COPD患者急性加重风险的曲线下面积(AUC,95%CI)为0.858(0.806-0.907),截点值9.73,特异度为81.81%,敏感度为84.31%.结论FAR与COPD患者的发病以及急性加重有关,且FAR越高,患者发生急性加重的风险越大,FAR有望作为早期诊断COPD患者急性加重的生物标志物.Objective To investigate the predictive value of fibrinogen(FIB)to albumin(ALB)ratio(FAR)in the risk o£acute exacerbation in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 95 patients with COPD who were admitted and diagnosed in our hospital from August 2019 to December 2020 were selected as the research subjects.According to whether there was recurrence of acute exacerbation in hospital within 1 year after discharge,they were divided into non-aggravated group(51 cases)and aggravated group(44 cases).The serum FIB level of the patients on admission was detected by automatic blood coagulation instrument,and the serum ALB level of the patients was detected by automatic biochemical analyzer,and FAR was calculated.Serum C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)levels were detected by ELISA.The correlation of FAR with CRP,IL-6 and TNF-a was explored by Pearson correlation analysis,and the predictive value o£FAR on the risk o£acute exacerbation in COPD patients was evaluated by ROC curve.Results The FAR,CRP,IL-6 and TNF-a of the COPD patients in aggravated group were higher than those in the nonaggravated group(P<0.05).The results of Pearson correlation analysis showed that FAR in COPD patients was positively correlated with serum CRP,IL-6 and TNF-α(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC,95%CI)of FAR for predicting the risk of acute exacerbation in COPD patients was 0.858(0.806-0.907),and the cutoff value was 9.73,the specificity 81.81%,and the sensitivity was 84.31%.Cone lusion FAR is related to the onset and acute exacerbation of COPD patients,and the higher the FARjhe greater the risk of acute exacerbation.FAR is expected to be used as a biomarker for early diagnosis of acute exacerbation in COPD patients.

关 键 词：纤维蛋白原与白蛋白比值 慢性阻塞性肺疾病 急性加重 预测价值 

分 类 号：R563.5[医药卫生—呼吸系统]