金黄色葡萄球菌感染相关毒力因子研究进展  

Research progress in infection-associated virulence factors of Staphylococcus aureus

作　　者：国康琳 余佳佳[1] 刘瑛[1] Guo Kanglin;Yu Jiajia;Liu Ying(Clinical Laboratory,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院检验科,200092

出　　处：《中华临床感染病杂志》2022年第1期51-56,70,共7页Chinese Journal of Clinical Infectious Diseases

摘　　要：金黄色葡萄球菌是人类感染性疾病的重要病原体,可导致皮肤软组织感染到心内膜炎、坏死性肺炎、骨髓炎等更严重的疾病。随着抗菌药物的使用,金黄色葡萄球菌也在不断进化产生耐药性,一个重要方面在于其分泌多种多样的毒力因子以侵袭感染人体。本文从金黄色葡萄球菌感染宿主的3个过程来综述各个阶段产生毒力因子的作用及研究进展,并简要介绍毒力因子的检测方法。Staphylococcus aureus is an important pathogen of human infectious diseases,which can cause skin and soft tissue infections,endocarditis,necrotizing pneumonia,myelitis and other serious infectious diseases.With the use of antibiotics,Staphylococcus aureus is evolving to develop drug resistance;at the same time it produces a variety of virulence factors to attack the host.This article will review the recent advances of Staphylococcus aureus virulence factors associated with the three stages of infection and introduce the detection methods of virulence factors briefly.

关 键 词：葡萄球菌 金黄色 毒力因子 生物膜 成孔毒素 剥脱毒素 超抗原 

分 类 号：R378.11[医药卫生—病原生物学]