放射性治疗药物的发展现状与展望  

Development Status and Prospect of Therapeutic Radiopharmaceuticals

作　　者：高洁 郑小北[3,4,5] 王红亮 李建国[2] 张岚[3,4] 杜进[1,7] GAO Jie;ZHENG Xiaobei;WANG Hongliang;LI Jianguo;ZHANG Lan;DU Jin(China Institute of Atomic Energy,Beijing 102413;China Institute for Radiation Protection Research and Development Center of Nuclear Technology(Non Clinical Evaluation of Radioactive Drugs)of National Atomic Energy Agency CNNC Key Laboratory on Radiotoxicology and Radiopharmaceutical Preclinical Evaluation Shanxi Key Laboratory of Drug Toxicology and Drug for Radiation Injury,Taiyuan 030006,China;Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China;Shanghai Vista Pharmaceutical Technology Co.Ltd,Shanghai 201815,China;University of Chinese Academy of Sciences,Beijing 100049,China;First Hospital of Shan Xi Medical University,Taiyuan 030001,China;China Isotope&Radiation Corporation,Beijing 100089,China)

机构地区：[1]中国原子能科学研究院,北京102413 [2]中国辐射防护研究院国家原子能机构核技术(放射性药物非临床评价)研发中心中核放射毒理与放射性药物临床前评价重点实验室药物毒理与放射损伤药物山西省重点实验室,太原030006 [3]中国科学院上海应用物理研究所,上海201800 [4]上海深景医药科技有限公司,上海201815 [5]中国科学院大学,北京100049 [6]山西医科大学第一医院,太原030001 [7]中国同辐股份有限公司,北京100089

出　　处：《同位素》2022年第3期151-163,共13页Journal of Isotopes

基　　金：核能开发后补助项目“放射性药物药物安全性评价关键技术研究”;中核集团青年英才项目“90Y微球临床前内照射对肝脏耐受剂量的研究”。

摘　　要：放射性治疗药物是将放射性核素与载体结合,利用放射性核素适宜的射线能量和在组织中的射程,选择性集中照射病变组织,同时避免正常组织受损并获得预期治疗效果,现主要用于肿瘤治疗或缓解肿瘤相关症状等。放射性药物广泛应用于肿瘤诊疗、心肌显像、神经退行性疾病早期发现和炎症组织显像诊断等。近年来,随着靶向性配体的快速发展,以及新型医用核素广泛应用,放射性治疗药物受到了越来越多的关注,目前^(153)Sm、^(89)Sr、^(223)Ra、^(90)Y、^(131)I和^(177)Lu等核素常用于治疗癌症骨转移、肝癌、甲状腺癌等,且治疗上显示出较大潜力,相关放射性治疗药物的研究也迅速增加。本文就已上市和研究阶段放射性治疗药物的临床应用和发展现状进行介绍,以期为我国放射性治疗药物的研发提供参考。Therapeutic radiopharmaceuticals combine radionuclides with carriers.It uses radionuclide suitable radiation energy and range in the tissue,selectively concentrated irradiation of diseased tissue,while avoiding damage to normal tissue and achieving the desired therapeutic effect.It is mainly used for cancer treatment or relief of tumor-related symptoms.It is widely used in tumor diagnosis and treatment,myocardial imaging,early detection of neurodegenerative diseases and imaging diagnosis of inflammatory tissues.In recent years,with the rapid development of targeted ligands and the wide application of new medical nuclides,radiotherapeutic drugs have attracted more and more attention.At present,nuclides such as ^(153)Sm,^(89)Sr,^(223)Ra,^(90)Y,^(131)I and ^(177)Lu are commonly used to treat cancer,bone metastasis,liver cancer and thyroid cancer,and show exciting potential in treatment.The research on radiotherapeutic drugs is also increasing rapidly.The clinical application and development status of radiopharma in the market and in the research stage are briefly introduced,in order to provide reference for the research and development of radiopharma in China.

关 键 词：放射性治疗药物 临床应用 研发 现状 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817.9[医药卫生—影像医学与核医学]