DGA树脂辅助的循环淋洗技术制备无载体镥[177Lu]  

Preparation of No-Carrier-Added ^(177)Lu by DGA Resin Assisted Cyclic Elution

作　　者：卓连刚 杨宇川[1,2] 岳海东 熊晓玲 王关全[1] 王海麟[1] 杨林 林青川 陈琪萍[1] 涂俊[1] 魏洪源[1] ZHUO Liangang;YANG Yuchuan;YUE Haidong;XIONG Xiaoling;WANG Guanquan;WANG Hailin;YANG Lin;LIN Qingchuan;CHEN Qiping;TU Jun;WEI Hongyuan(China Academy of Engineering PhysicsInstitute of Nuclear Physics and Chemistry,Mianyang 621999 China;NHC Key Laboratory of Nuclear Technology Medical Transformatio,Mianyang 621099,China;Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province,Mianyang 621999,China)

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621999 [2]国家卫生健康委员会核技术医学转化重点实验室(绵阳市中心医院),四川绵阳621099 [3]医学与分子影像四川省重点实验室,四川绵阳621999

出　　处：《同位素》2022年第3期217-223,共7页Journal of Isotopes

基　　金：四川省重大科技专项资助(2019ZDZX0012);科工局核能开发项目资助(20201192)。

摘　　要：为实现核医学广泛关注的新型医用放射性同位素^(177)Lu的国产规模化,利用中国绵阳反应堆(CMRR)进行无载体(n.c.a.)^(177)Lu的制备工艺研究。在常规的镧系树脂分离纯化^(177)Lu的流程中加入可以吸附洗脱液中金属离子的DGA树脂柱,并通过特殊的流路连接方式,实现淋洗镧系树脂柱洗脱液的“在线”循环。示踪实验和三次生产流程验证表明,第一级分离的废液量降低>86%。质检分析表明,循环淋洗技术制备的无载体^(177)Lu产品符合质量要求。研究表明,该技术显著降低了镧系树脂分离无载体^(177)Lu中的放射性酸废液总量,可用于规模化生产工艺。A preparation process of No-Carrier-Added(NCA) ^(177)Lu in China Mianyang Research Reactor(CMRR)was investigated. In this work, the key component of the process is DGA resin column which can adsorb Yb(Ⅲ) and Lu(Ⅲ) metal ions in the eluent was added to the purification process of ^(177)Lu. The eluent “on-line” cyclic elution of lanthanide resin column was realized through special flow path connection. The tracer test showed that this technology can effectively reduce the volume of radioactive acid waste liquid generated from purification process of ^(177)Lu. The technology was verified in three batches production, and the primary separation stage reduced the volume of waste liquid above 86%. The NCA ^(177)Lu product prepared by cyclic elution process meets the quality requirements.

关 键 词：无载体^(177)Lu 医用同位素^(177)Lu分离 DGA树脂 

分 类 号：TL92[核科学技术—核燃料循环与材料]