细菌纤维素/功能化石墨烯复合材料的制备及抗菌研究  

Preparation and antimicrobial properties of bacterial cellulose/ functionalized graphene composites

作　　者：王学洋 钟成 崔吉晓 杨颖 胡晓慧 辛波 WANG Xueyang;ZHONG Cheng;CUI Jixiao;YANG Ying;HU Xiaohui;XIN Bo(Key Laboratory of Microorganism for Industrial Fermentation of the Ministry of Education,College of Bioengineering,Tianjin University of Science and Technology,Tianjin 300457,China;Tianjin Ringpu Bio-technology Co.,Ltd.,Tianjin 300308,China)

机构地区：[1]天津科技大学生物工程学院工业发酵微生物教育部重点实验室,天津300457 [2]天津瑞普生物技术股份有限公司,天津300308

出　　处：《生物加工过程》2022年第3期299-306,共8页Chinese Journal of Bioprocess Engineering

基　　金：国家自然科学基金(21978219);天津市科技支撑计划重点项目(20YFZCSN00120)。

摘　　要：细菌纤维素(bacterial cellulose,BC)是一种天然的纯纤维素高分子基材,本身并无抑菌活性,在一定程度上限制了其在生物医学、环境等领域的应用。氧化石墨烯(GO)及其衍生物具备比表面积大、含有大量含氧官能团等特性,将其负载到BC上可以赋予BC一定的抑菌能力。SnO_(2)纳米粒子具有良好的光催化活性,可将其与其他材料复合,从而增强材料的抑菌效果。采用SnO_(2)纳米粒子对GO的表面进行原位修饰,成功制备了rGO-SnO_(2)纳米复合物。以BC作为基材,通过匀浆共混法将纳米复合物填充到BC基质中,得到具备光催化作用的BC/rGO-SnO_(2)复合材料。该材料在紫外光下2 h对于亚甲基橙(MO)染料的降解率达93.4%,近紫外光催化条件下对S.aureus的抑制率可达52.12%。该复合材料在生物医学、环境等领域具有较大的应用潜力。Bacterial cellulose(BC) is a natural pure cellulose polymer substrate,but its application in biomedical and environmental fields is limited to some extent due to its lack of antibacterial activity.Graphene oxide(GO) and its derivatives,with large specific surface area and a large number of oxygen-containing functional groups,can be loaded onto BC to give it certain antibacterial ability.SnO_(2) nanoparticles have good photocatalytic activity to,be combined with other materials to enhance the antibacterial effect of the material.In this paper,rGO-SnO_(2) nanocomposites were successfully prepared by in-situ modification of GO surface with SnO_(2) nanoparticles.The photocatalytic BC/rGO-SnO_(2) composite was obtained by filling the nanocomposites into BC matrix by homogenization.The degradation rate of methylene orange(MO) dye under ultraviolet light was 93.4% for 2 h,and the inhibition rate of S.aureus under near ultraviolet light was 52.12%.The composite material has great application potential in biomedical and environmental fields.

关 键 词：细菌纤维素 石墨烯 功能性修饰 光催化 抑菌性能 抑菌机制 SnO_(2) 

分 类 号：TQ352.79[化学工程] R318.08[医药卫生—生物医学工程]