中文版Morisky用药依从性问卷在肾病综合征患儿中的信效度评价及应用  

Reliability and Validity Evaluation and Application of the Chinese Version of Morisky Medication Adherence Scale in Children with Nephrotic Syndrome

作　　者：何振济 陈碧[1] 李辉[1] 杨度[1] 李玮 He Zhenji;Chen Bi;Li Hui;Yang Du;Li Wei(Chenzhou First People's Hospital,Hunan Chemhou 423000,China)

机构地区：[1]郴州市第一人民医院,湖南郴州423000

出　　处：《儿科药学杂志》2022年第6期25-29,共5页Journal of Pediatric Pharmacy

基　　金：郴州市第一人民医院院内科研项目,编号N2020-28;郴州市技术创新引导项目,编号lcyl2021077。

摘　　要：目的:评价中文版Morisky用药依从性问卷(MMAS-8)在肾病综合征(NS)患儿中应用的信度和效度,探讨本地区NS患儿的用药依从性水平及影响因素。方法:应用中文版MMAS-8对就诊于我院的90例NS患儿开展用药依从性问卷调查。选用Cronbachα系数评价中文版MMAS-8内部一致性信度,组内相关系数(ICC)评价重测信度;选用主成分因子分析法评价结构效度;选用Pearson相关系数评价MMAS-8得分与6个月内复发次数的相关性;对NS患儿的用药依从性影响因素选用多因素多分类有序Logistic回归分析。结果:中文版MMAS-8的Cronbachα系数为0.751;ICC为0.865(P<0.05);主成分因子分析共提取3个公因子;调查的90例患儿中有78.89%的患儿用药依从性不佳(评分<8分);患儿6个月内复发次数与MMAS-8得分存在中度的负相关(Pearson相关系数为-0.454,P<0.01);用药依从性影响因素分析结果显示,病程<1年较病程>3年患儿的用药依从性好(P<0.05),由父母监督服药较自行服药的患儿用药依从性好(P<0.05),患儿及家属对疾病了解越多用药依从性越好(P<0.05)。年龄、性别、复发次数对服药依从性无显著影响(P>0.05)。结论:中文版MMAS-8具有较好的信度和效度,可用于评估NS患儿的用药依从性。本地区NS患儿用药依从性水平不高,与患儿病程、用药监护人、是否了解疾病基本知识有关。Objective:To evaluate the reliability and validity of the Chinese version of Morisky medication adherence scale(MMAS-8)in children with nephrotic syndrome(NS),and to explore the medication adherence level and influencing factors of children with NS in this region.Methods:The Chinese version of MMAS-8 was used to investigate the medication adherence of 90 children with NS in our hospital.Cronbachαcoefficient was used to evaluate the internal consistency reliability of the Chinese version of MMAS-8,the intragroup correlation coefficient(ICC)was used to evaluate the test-retest reliability,the principal component factor analysis method was used to evaluate the structural validity.Pearson correlation coefficient was used to evaluate the correlation between MMAS-8 score and the number of recurrences within 6 months.Influencing factors of medication adherence in children with NS were analyzed by multi-factor ordered multi-class Logistic regression.Results:The Cronbachαcoefficient of the Chinese version of MMAS-8 was 0.751,the ICC was 0.865(P<0.05).Three common factors were extracted by principal component factor analysis,78.89%of the 90 children surveyed had poor medication adherence(<8 points).There was moderate negative correlation between the number of recurrences within 6 months and the score of MMAS-8(Pearson correlation was-0.454,P<0.01).Results of influencing factors of medication adherence showed that children with disease course less than 1 year had better medication adherence than those with the course of disease more than 3 years(P<0.05),children with parental supervision had better medication adherence than those with self-medication(P<0.05),and the more the children and their families knew about the disease,the better the medication adherence(P<0.05).Age,gender and number of recurrences had no statistical significance on medication adherence(P>0.05).Conclusion:The Chinese version of MMAS-8 has good reliability and validity,and can be used to assess the medication adherence of children with NS.The level o

关 键 词：肾病综合征 用药依从性 Morisky用药依从性量表 信效度 影响因素 

分 类 号：R969.3[医药卫生—药理学]