滋肾宁心胶囊治疗围绝经期高血压的疗效及对性激素水平、胰岛素抵抗的影响  

Efficacy of Zishen Ningxin Capsules in the Treatment of Perimenopausal Hypertension and Its Effect on Sex Hormone Level and Insulin Resistance

作　　者：王蓓 杜明民 张晶 王成益 王强[1] 付达[1] WANG Bei;DU Mingmin;ZHANG Jing;WANG Chengyi;WANG Qiang;FU Da(Dept.of Cardiology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China;Dept.of Gastroenterology,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China;Dept.of Internal Medicine,Tangshan Fengnan District Hospital of Traditional Chinese Medicine,Hebei Tangshan 063300,China)

机构地区：[1]石家庄市中医院心病科,石家庄050000 [2]河北省中医院脾胃科,石家庄050000 [3]唐山市丰南区中医医院内科,河北唐山063300

出　　处：《中国医院用药评价与分析》2022年第5期556-559,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局科研计划项目(No.2021255)。

摘　　要：目的:探讨滋肾宁心胶囊治疗围绝经期高血压的疗效及对性激素水平、胰岛素抵抗的影响。方法:选择2020年9月至2021年6月于石家庄市中医院治疗的围绝经期高血压患者100例,以随机数字表法分为对照组和研究组,每组50例。对照组患者给予缬沙坦片治疗,研究组患者加用滋肾宁心胶囊,疗程为1个月。分别于治疗前后,检测两组患者睾酮(T)、孕酮(P)、性激素结合蛋白(SHGB)、雌二醇(E_(2))、神经降压素(NT)、神经肽Y(NPY)、前列环素(PGI_(2))、血管紧张素Ⅱ(AngⅡ)、Chemerin蛋白、舒张压和收缩压水平,计算胰岛素抵抗指数(HOMA-IR),进行Kupperman评分及中医证候评价,比较两组患者的临床疗效。结果:与对照组相比,研究组患者治疗后E;、SHBG、NT和PGI;水平升高,NPY、AngⅡ、P和T水平降低,Chemerin蛋白、HOMA-IR水平降低,舒张压、收缩压水平降低,Kupperman评分、中医证候评分降低,差异均有统计学意义(P<0.05)。研究组患者的总有效率为96.00%(48/50),高于对照组(80.00%,40/50),差异有统计学意义(P<0.05)。结论:滋肾宁心胶囊治疗围绝经期高血压,可改善患者性激素紊乱状态,调节NT、PGI_(2)、AngⅡ和NPY水平,改善血压及胰岛素抵抗,提高临床疗效。OBJECTIVE: To probe into the efficacy of Zishen Ningxin capsules in the treatment of perimenopausal hypertension and its effect on sex hormone level and insulin resistance. METHODS: Totally 100 patients with perimenopausal hypertension admitted into Shijiazhuang Hospital of Traditional Chinese Medicine from Sept. 2020 to Jun. 2021 were selected and randomly divided into control group and research group, with 50 cases in each group. The control group was given valsartan tablets, while the research group were given Zishen Ningxin capsules based on the control group, both group were treated for 1 month. The testosterone(T), progesterone(P), sex hormone binding protein(SHGB), estrogen(E_(2)), neurotensin(NT), neuropeptide Y(NPY), prostacyclin(PGI_(2)), angiotensin Ⅱ(AngⅡ), Chemerin protein, diastolic blood pressure and systolic blood pressure levels were measured before and after treatment, the insulin resistance index(HOMA-IR) was calculated, Kupperman score and traditional Chinese medicine(TCM)syndrome evaluation were performed on the patients, so that the clinical efficacy was compared between two groups. RESULTS: Compared with the control group, the E_(2), SHBG, NT and PGI;levels of research group were increased after treatment, the NPY, AngⅡ, P, T, Chemerin protein, HOMA-IR, diastolic blood pressure and systolic blood pressure levels, Kupperman score and TCM syndrome integral of research group were decreased after treatment, with statistically significant differences(P<0.05). The total effective rate of research group was 96.00%(48/50), which was higher than 80.00%(40/50) in the control group, with statistically significant difference(P<0.05). CONCLUSIONS: Zishen Ningxin capsules for the treatment of perimenopausal hypertension can improve patients’ sex hormone disorder, regulate NT, PGI_(2), AngⅡ and NPY levels, improve blood pressure and insulin resistance, and promote the clinical efficacy.

关 键 词：滋肾宁心胶囊 围绝经期高血压 性激素 神经降压素 神经肽Y 胰岛素抵抗 KUPPERMAN评分 

分 类 号：R932[医药卫生—生药学]