醒脑静注射液联合盐酸纳洛酮治疗老年急性脑卒中合并意识障碍患者的疗效及对Lp-PLA2、BDNF和GCS的影响  

Efficacy of Xingnaojing Injection Combined with Naloxone Hydrochloride on Senile Patients with Acute Stroke Complicated with Disturbance of Consciousness and Its Effects on Lp-PLA2,BDNF and GCS

作　　者：戴伍妹 焦黛妍 DAI Wumei;JIAO Daiyan(Dept.of Emergency,Hai’an Hospital Affiliated to Nantong University,Jiangsu Haian 226600,China)

机构地区：[1]南通大学附属海安医院急诊科,江苏海安226600

出　　处：《中国医院用药评价与分析》2022年第5期588-591,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：南通市2018年度市级科技计划项目(No.MSZ18241)。

摘　　要：目的:探讨醒脑静注射液联合盐酸纳洛酮治疗老年急性脑卒中合并意识障碍患者的效果和安全性。方法:将2019年1月至2020年12月该院95例急性脑卒中合并意识障碍的老年患者以住院号末尾单双数的随机数字表法分为观察组(52例)和对照组(43例)。在常规救治措施的基础上,对照组患者采用盐酸纳洛酮注射液治疗,观察组患者采用醒脑静注射液联合盐酸纳洛酮注射液治疗。观察两组患者炎症因子、神经细胞因子和神经功能指标的变化,以及疗效和安全性。结果:治疗2周后,观察组患者的血清脂蛋白相关磷脂酶A2、可溶性白细胞介素2受体和神经元特异性烯醇化酶水平明显低于对照组,脑源性神经细胞营养因子水平明显高于对照组,差异均有统计学意义(P<0.05);观察组患者的美国国立卫生研究院卒中量表评分明显低于对照组,格拉斯哥昏迷量表评分明显高于对照组,差异均有统计学意义(P<0.05);观察组患者的总有效率(96.15%,50/52)明显高于对照组(83.72%,36/43),意识恢复时间、住院时间明显短于对照组,心血管不良事件发生率(3.85%,2/52)明显低于对照组(9.30%,4/43),差异均有统计学意义(P<0.05)。两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:醒脑静注射液能减轻老年急性脑卒中合并意识障碍患者的炎症状态,调节神经细胞因子水平,促进意识水平恢复,改善疾病预后,用药安全性较高。OBJECTIVE: To probe into the efficacy and safety of Xingnaojing injection combined with naloxone hydrochloride on senile patients with acute stroke complicated with disturbance of consciousness. METHODS: Totally 95 senile patients with acute stroke complicated with disturbance of consciousness admitted from Jan. 2019 to Dec. 2020 were extracted to be divided into the observation group(n=52) and the control group(n=43) via random number table method with odd and even numbers at the end of hospitalization number. On the basis of conventional treatment, the control group was treated with naloxone hydrochloride injection, while the observation group received Xingnaojing injection combined with naloxone hydrochloride injection. Changes of inflammatory factors, nerve cytokines, nerve function indexes, efficacy and safety were observed in two groups. RESULTS: After treatment of two weeks, the levels of serum lipoprotein associated phospholipase A2, soluble interleukin-2 receptor, neuron specific enolase in the observation group were significantly lower than those in the control group, and the level of brain-derived neurotrophic factor was significantly higher than that in the control group, with statistically significant difference(P<0.05). The national institutes of health stroke scale in the observation group was lower than that of the control group, and the Glasgow coma score was higher than that of the control group, with statistically significant difference(P<0.05). The total effective rate in the observation group(96.15%,50/52) was significantly higher than that in the control group(83.72%,36/43), the recovery time and length of stay were significantly shorter than those in the control group, and the incidence of cardiovascular adverse events(3.85%,2/52) was significantly lower than the control group(9.30%,4/43), and the difference was statistically significant(P<0.05). There was no statistical significance in the incidence of adverse drug reactions between two groups(P>0.05). CONCLUSIONS: Xingnaojing injection ca

关 键 词：急性脑卒中 意识障碍 醒脑静注射液 炎症因子 神经细胞因子 安全性 

分 类 号：R932[医药卫生—生药学]