冠心病患者血清VASP和PAPP-A的表达水平与冠状动脉病变程度的相关性研究  

Study on the Correlation between the Expression Levels of Serum VASP and PAPP-A and the Severity of Coronary Artery Disease in Patients with Coronary Heart Disease

作　　者：李欢 焦峰军 苏颜平 LI Huan;JIAO Feng-jun;SU Yan-ping(Department of Cardiology,the First People’s Hospital of Xianyang,Shaanxi Xianyang 712000,China;Department of Pharmacy,the First People’s Hospital of Xianyang,Shaanxi Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院心内科,陕西咸阳712000 [2]咸阳市第一人民医院药剂科,陕西咸阳712000

出　　处：《现代检验医学杂志》2022年第3期114-118,共5页Journal of Modern Laboratory Medicine

摘　　要：目的研究冠心病(coronary heart disease,CHD)患者血清血管扩张刺激磷蛋白(vasodilator stimulated phosphoprotein,VASP)和妊娠相关血浆蛋白A(pregnancy associated plasma protein-A,PAPP-A)的表达水平与病变程度的关系。方法纳入2017年12月~2019年12月期间咸阳市第一人民医院心内科收治的200例CHD患者作为研究对象,另纳入同期健康体检受试者100例作为对照组,收集和检测所有受试者的一般资料、生化指标、血清VASP和PAPP-A的表达水平,以心脏外科与介入治疗狭窄冠状动脉研究(SYNTAX)积分评价冠状动脉病变严重程度,对各指标进行Pearson相关性分析和多元线性回归分析。结果与对照组相比,研究组患者FBG(6.55±1.33 mmol/L vs 4.92±0.83 mmol/L),FINS(9.92±3.11 mIU/L vs 5.34±2.09 mIU/L),HbA1c(8.50%±1.30%vs 6.24%±0.26%)和PAPP-A(17.93±5.14 mIU/L vs 10.43±2.96 mIU/L)的水平均显著升高,血清VASP(290.77±57.88 ng/L vs 406.64±81.81 ng/L)的表达水平显著降低,差异均有统计学意义(t=11.208~23.657,均P<0.001)。与SAP组相比,UAP组和AMI组患者血清VASP(286.21±59.78 ng/L,225.85±54.09 ng/L vs 352.22±66.12ng/L)的表达水平较低,而PAPP-A(18.01±4.52 mIU/L,26.71±5.59 mIU/L vs 13.23±3.14mIU/L)的表达水平均较高,差异有统计学意义(F=69.261,144.405,均P<0.001);三组其余指标相比差异均无统计学意义(F=0.210~2.363,均P>0.05)。SYNTAX积分23~32分患者组的血清VASP表达水平显著低于、而PAPP-A显著高于0~22分患者组;≥33分患者组的血清VASP表达水平显著低于、而PAPP-A显著高于0~22分以及23~32分患者组,差异均有统计学意义(F=67.098,139.984,均P<0.001)。Pearson相关性分析显示,血清VASP的表达水平与SYNTAX积分呈负相关(r=-0.208,P<0.05),PAPP-A的表达水平与SYNTAX积分呈正相关(r=0.233,P<0.05)。多元线性回归分析显示,血清VASP(β=0.620,P=0.008)和PAPP-A(β=0.884,P=0.005)的表达水平是SYNTAX积分的独立影响因素。结论CHD患者血清VASP和PAPP-A的表Objective To investigate the correlation between expression levels of serum vasodilator stimulated phosphoprotein(VASP),pregnancy associated plasma protein-A(PAPP-A)and coronary lesion degree in patients with coronary heart disease(CHD).Methods 200 patients with CHD admitted to department of cardiology of the First People’s Hospital of Xianyang from December 2017 to December 2019 were accepted as research subjects,and 100 healthy subjects were collected as control group.The general information,biochemical indexes and expression levels of serum VASP and PAPP-A were collected and detected,and the coronary lesion degree was evaluated by SYNTAX.The correlation analysis and multiple linear regression analysis were conducted.Results Compared with the control group,the levels of FBG(6.55±1.33 mmol/L vs 4.92±0.83mmol/L),FINS(9.92±3.11 mIU/L vs 5.34±2.09 mIU/L),HbA1c(8.50%±1.30%vs 6.24%±0.26%)and PAPP-A(17.93±5.14 mIU/L vs 10.43±2.96 mIU/L)in the study group were significantly increased,and the expression level of serum VASP(290.77±57.88 ng/L vs 406.64±81.81 ng/L)was significantly reduced,the differences were statistically significant(t=11.208~23.657,all P<0.001).Compared with the SAP group,the serum VASP(286.21±59.78 ng/L,225.85±54.09 ng/L vs 352.22±66.12ng/L)was lower in UAP group and AMI group,while PAPP-A(18.01±4.52 mIU/L,26.71±5.59 mIU/L vs 13.23±3.14mIU/L)the expression level of higher,the differences were statistically significant(F=69.261,144.405,均P<0.001).There was no statistically significant difference among the remaining indicators of the three groups(F=0.210~2.363,all P>0.05).The expression levels of serum VASP of patients with 23~32 SYNTAX points were lower while PAPP-A were higher than patients with 0~22 SYNTAX points(F=67.098,139.984,all P<0.001).The expression levels of serum VASP of patients with≥33 SYNTAX points were lower while PAPP-A were higher than patients with 0~22 and 23~32 SYNTAX points(P<0.05).The Pearson correlation analysis showed that the expression levels of serum VASP

关 键 词：冠心病 血管扩张刺激磷蛋白 妊娠相关血浆蛋白A 冠状动脉病变程度 

分 类 号：R541.4[医药卫生—心血管疾病] R392.11[医药卫生—内科学]