谷胱甘肽联合维生素C治疗女性黄褐斑的临床疗效及对雌孕激素水平的影响  

Clinical efficacy of glutathione combined with vitamin C in the treatment of female chloasma and its effect on estrogen and progesterone levels

作　　者：林春生[1] LIN Chunsheng(Department of Dermatology,Guangzhou Institute of Dermatology,Guangdong,Guangzhou,510000,China)

机构地区：[1]广州市皮肤病防治所中西医结合皮肤科,广东广州510000

出　　处：《当代医学》2022年第15期60-62,共3页Contemporary Medicine

摘　　要：目的探讨谷胱甘肽联合维生素C治疗女性黄褐斑的临床疗效及对雌孕激素水平的影响。方法选取2019年1—12月本院皮肤科收治的80例女性黄褐斑患者作为研究对象,采用红蓝数字抽签法分为单一组和双重组,每组40例。单一组给予常规维生素C治疗,双重组在单一组基础上联合谷胱甘肽治疗,比较两组临床疗效和治疗前后色斑面积、色斑颜色、皮肤病生活质量指数(DLQI)评分、雌二醇(E_(2))、孕酮(P)水平及不良反应发生率。结果双重组治疗总有效率为95.00%,高于单一组的80.00%,差异有统计学意义(P<0.05)。治疗后,双重组色斑面积小于单一组,色斑颜色淡于单一组,DLQI评分低于单一组,差异有统计学意义(P<0.05)。治疗后,双重组E_(2)水平低于单一组,P水平高于单一组,差异有统计学意义(P<0.05)。双重组不良反应发生率为7.50%,低于单一组的25.00%,差异有统计学意义(P<0.05)。结论谷胱甘肽联合维生素C治疗女性黄褐斑效果显著,能快速促进E_(2)与P水平恢复,有效消减脸部色斑面积和颜色,降低不良反应发生率,临床可依据患者实际情况酌情借鉴和推广。Objective To explore the clinical efficacy of glutathione combined with vitamin C in the treatment of female chloasma and its effect on estrogen and progesterone levels.Methods 80 cases of female chloasma patients admitted to the department of Dermatology of our hospital from January to December 2019 were selected as the research subjects,and they were divided into single group and double group according to red and blue digital lottery method,with 40 cases in each group.The single group was given routine vitamin C treatment,and the double group was given glutathione treatment on the basis of the single group,the clinical efficacy,pigmentation area,pigmentation color,dermatological life quality index(DLQI)score,estradiol(E_(2)),progesterone(P)levels before and after treatment,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the double group was 95.00%,which was significantly higher than 80.00%of the single group,and the difference was statistically significant(P<0.05).After treatment,the pigmentation area of the double group was significantly smaller than that of the single group,the pigmentation color was significantly lighter than that of the single group,and the DLQI scores was significantly lower than that of the single group,and the difference was statistically significant(P<0.05).After treatment,the E_(2) level of the double group was significantly lower than that of the single group,and the P level was higher than that of the single group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the double group was 7.50%,which was significantly lower than 25.00%in the single group,and the difference was statistically significant(P<0.05).Conclusion Glutathione combined with vitamin C has significant effect in the treatment of female chloasma,can not only quickly promote the recovery of E_(2) and P levels,effectively reduce the area and color of facial pigmentation,but also reduce the incidence of adverse re

关 键 词：谷胱甘肽 皮肤病生活质量指数评分 黄褐斑 雌激素 孕激素 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]