单细胞测序和空间转录组学在心血管疾病研究中的进展  

Progress of single-cell RNA sequencing and spatial transcriptomics in cardiovascular diseases

作　　者：朱彬彬 刘亚慧 齐大屯[2] 程倩倩[2] 李高寒 高传玉 ZHU Bin-bin;LIU Ya-hui;QI Da-tun;CHENG Qian-qian;LI Gao-han;GAO Chuan-yu(Department of Cardiology,Zhengzhou University People’s Hospital,Henan Provincial People’s Hospital,Zhengzhou 450003,China;Zhengzhou University Central China Fuwai Hospital,Henan Provincial Key Lab for Control of Coronary Heart Disease,Zhengzhou 451464,China)

机构地区：[1]郑州大学人民医院,河南省人民医院心内科,河南省郑州市450003 [2]郑州大学华中阜外医院,河南省冠心病防治重点实验室

出　　处：《中国心血管病研究》2022年第6期497-502,共6页Chinese Journal of Cardiovascular Research

基　　金：国家重点研发计划数字诊疗装备研发重点专项2018年度定向项目(2018YFC0114500)。

摘　　要：近年来,我国心血管病的发病率和病死率不断上升,给社会和居民家庭带来沉重负担。除了控制血脂、血糖、戒烟等危险因素以外,需要在基础领域对心脏与血管组织细胞、发育与功能及发病机制进一步探索。单细胞测序技术(single-cell RNA sequencing,scRNA-seq)和空间转录组(spatial transcriptomic,ST)不仅可以发现全新的细胞类型,而且可以揭示每个细胞独特的变化,极大地推动了基因组学研究。通过研究不同细胞群体之间细胞动态通讯状态及调控通路,探讨研究疾病过程中的分子机制。In recent years, the incidence and mortality of cardiovascular diseases in China have been increasing, which has brought a heavy burden to society and households. In addition to controlling blood lipids,blood glucose, smoking cessation and other risk factors, the heart and vascular tissue cells, development and function and pathogenesis need to be further explored in the basic field. Single-cell RNA sequencing(scRNA-seq)technology and spatial transcriptomic(ST) can not only discover new cell types, but also reveal unique changes in each cell, greatly promoting genomics research. By studying the dynamic cellular communication status and regulatory pathways between different cell populations, the molecular mechanism in the process of disease research was explored.

关 键 词：单细胞测序 空间转录组 冠心病 瓣膜病 心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]