全凭静脉麻醉和静吸复合麻醉对老年肺癌根治术患者麻醉质量及术后认知功能的影响  

Effects of total intravenous anesthesia and intravenous-inhalation combined anesthesia on anesthesia quality and postoperative cognitive function in elderly patients undergoing radical resection of lung cancer

作　　者：刘学佳[1] 丁保峰[1] 杨春晓[1] 邢小明[1] 井玉生[1] LIU Xue-jia;DING Bao-feng;YANG Chun-xiao;XING Xiao-ming;JING Yu-sheng(Department of Anesthesiology,the Second People's Hospital of Liaocheng,Liaocheng 252600,Shandong,China)

机构地区：[1]聊城市第二人民医院麻醉科,山东聊城252600

出　　处：《川北医学院学报》2022年第6期780-783,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨全凭静脉麻醉和静吸复合麻醉对老年肺癌根治术患者麻醉质量、应激反应指标及术后认知功能的影响。方法:选取110例肺癌根治术的老年患者为研究对象,按照麻醉方式不同分为观察组(n=58)和对照组(n=52)。观察组患者行全凭静脉麻醉;对照组患者行静吸复合麻醉。比较两组患者围术期指标、麻醉质量、应激反应、血流动力学和认知功能。结果:观察组患者插管时间、麻醉时间、麻醉起效时间、睁眼时间、定向力恢复时间、听从指令时间低于对照组(P<0.05)。T_(1)、T_(2)、T_(3)时,观察组肾上腺素(E)、心率(HR)水平低于对照组(P<0.05)。麻醉后12 h、24 h,观察组MMSE评分高于对照组(P<0.05)。结论:全凭静脉麻醉和静吸复合麻醉应用于老年肺癌根治术均有良好效果,但全凭静脉麻醉麻醉质量更好,对患者应激反应、术后短期认知功能的影响较小。Objective:To investigate the effects of total intravenous anesthesia and intravenous-inhalation combined anesthesia on anesthesia quality,stress response indicators and postoperative cognitive function in elderly patients undergoing radical resection of lung cancer.Methods:110 elderly patients undergoing radical resection of lung cancer were selected as the research objects.They were divided into observation group(n=58,total intravenous anesthesia)and control group(n=52,intravenous-inhalation combined anesthesia).The perioperative indicators,anesthesia quality,stress response,hemodynamics and cognitive function were compared between the two groups.Results:The intubation time,anesthesia time,anesthesia onset time,eye-opening time,orientation recovery time and time of following instructions in observation group were shorter than those in control group(P<0.05).At T_(1),T_(2)and T_(3),the levels of epinephrine(E)and heart rate(HR)in observation group were lower compared with those in control group(P<0.05).The MMSE scores in observation group at 12 h and 24 h after anesthesia were higher than those in control group(P<0.05).Conclusion:Total intravenous anesthesia and intravenous-inhalation combined anesthesia can achieve significant results in radical resection of lung cancer in the elderly,but total intravenous anesthesia has better anesthesia quality and has less impact on stress response and short-term postoperative cognitive function.

关 键 词：全凭静脉麻醉 静吸复合麻醉 老年 肺癌根治术 认知功能 

分 类 号：R614[医药卫生—麻醉学]