NapsinA、CGA及CK7在肺癌患者中的表达及与临床病理的关系分析  

Expressions of NapsinA,CGA and CK7 in patients with lung cancer and their relationship with clinicopathology

作　　者：黄玉惠 余婧 李景 HUANG Yu-hui;YU Jing;LI Jing(Department of Pathology,the First People's Hospital of Shuangliu District,Chengdu 610200,Sichuan,China)

机构地区：[1]成都市双流区第一人民医院病理科,四川成都610200

出　　处：《川北医学院学报》2022年第6期784-788,共5页Journal of North Sichuan Medical College

摘　　要：目的:探讨天门冬氨酸蛋白酶A(NapsinA)、嗜铬粒蛋白A(CGA)及细胞角蛋白7(CK7)在肺癌患者中的表达及与临床病理的关系。方法:收集109例肺癌患者的癌组织及癌旁组织标本,检测NapsinA、CGA、CK7在癌组织及癌旁正常组织的表达情况,分析其表达与临床病理的关系。结果:NapsinA、CGA、CK7在肺癌组织中阳性率高于癌旁组织(P<0.05)。病理类型为肺腺癌、TNM分期越晚、存在淋巴结转移的患者肺组织内NapsinA阳性表达率越高,TNM分期越晚的患者肺组织内CGA阳性表达率越高,TNM分期越晚、存在淋巴结转移的患者肺组织内CK7阳性表达率越高。NapsinA、CGA、CK7阳性患者预后较差,中位生存期均低于NapsinA、CGA和CK7阴性患者(P<0.05)。结论:NapsinA、CGA、CK7可作为评估肺癌患者预后的重要生物标志物之一。Objective:To explore the expressions of novel aspartie proteinase A(NapsinA),chromogranin A(CGA)and cytokeratin 7(CK7)in patients with lung cancer and their relationship with clinicopathology.Methods:109 patients with lung cancer were selected as the research subjects.The lung cancer tissues and adjacent tissues specimens of the patients were taken to detect the expressions of NapsinA,CGA and CK7 in cancer tissues and adjacent normal tissues,and the relationship between their expressions and clinicopathology was analyzed.Results:The positive rates of NapsinA,CGA and CK7 in lung cancer tissues were higher than those in adjacent tissues(P<0.05).The positive expression rate of NapsinA was higher in lung tissues of patients with pathological type of lung adenocarcinoma,later TNM stage and lymph node metastasis.The positive expression rate of CGA in lung tissues was higher in patients with later TNM stage,and the positive expression rate of CK7 was higher in lung tissues of patients with later TNM stage and presence of lymph node metastasis.The prognosis was poor among patients with positive NapsinA,CGA and CK7,and the median survival time was significantly shorter than that of patients with negative NapsinA,CGA and CK7(P<0.05).Conclusion:NapsinA,CGA and CK7 can be used as one of the important biomarkers to evaluate the prognosis of patients with lung cancer.

关 键 词：肺癌 癌组织 癌旁组织 天门冬氨酸蛋白酶A 嗜铬粒蛋白A 细胞角蛋白7 临床病理 

分 类 号：R563[医药卫生—呼吸系统]